The influence of influenza virus infections on the development of tuberculosis

Ralf Paus, Roelof A. De Paus, Reinout Van Crevel, Ruud Van Beek, Edhyana Sahiratmadja, Bachti Alisjahbana, Sangkot Marzuki, Guus F. Rimmelzwaan, Jaap T. Van Dissel, Tom H M Ottenhoff, Esther Van De Vosse

    Research output: Contribution to journalArticlepeer-review


    Recently, it was shown that interferon-γ mediated immune responses, which play a major role in the control of infection with Mycobacterium tuberculosis (Mtb), can be inhibited by type I interferons. Since type I interferons are abundantly induced during viral infections, we hypothesized that infections with influenza viruses might play a role in the development of active TB disease either directly after exposure to Mtb or through reactivation of latent Mtb infection. To explore this hypothesis we investigated in a retrospective study whether newly diagnosed adult tuberculosis patients from Indonesia had had recent influenza infection. Plasma samples from TB patients and controls were assayed for antibodies against two subtypes of at that time relevant, seasonal influenza A viruses. Overall, no correlation was observed with the presence of antibodies and manifest tuberculosis. Still, antibody titers against circulating A/H3N2 influenza virus were slightly enhanced in tuberculosis patients as compared to controls, and highest in cases of advanced tuberculosis. This suggests that tuberculosis patients were recently infected with influenza, before clinical manifestation of the disease. Alternatively, the production of antibodies and susceptibility to tuberculosis may be influenced by a common confounding factor, for example the ability of patients to induce interferon-α. We conclude that in an endemic country like Indonesia, an influenza virus infection is not a major determinant for developing clinically manifest tuberculosis. © 2013 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)338-342
    Number of pages4
    Issue number3
    Publication statusPublished - May 2013


    • Co-infection
    • Influenza
    • Interferon
    • Reactivation
    • Susceptibility
    • Tuberculosis


    Dive into the research topics of 'The influence of influenza virus infections on the development of tuberculosis'. Together they form a unique fingerprint.

    Cite this