The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival

Adele Green; Aaron P. Thrift; Christina M. Nagle; Paul P. Fahey; Anne Russell; Bernard M. Smithers; David I. Watson; David C. Whiteman

doi:10.1002/ijc.27420

The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival

Adele Green, Aaron P. Thrift, Christina M. Nagle, Paul P. Fahey, Anne Russell, Bernard M. Smithers, David I. Watson, David C. Whiteman

Research output: Contribution to journal › Article › peer-review

Abstract

Demographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of esophageal squamous cell carcinoma (ESCC); however, little is known about the effect of these factors on survival. We included all 301 patients with incident ESCC, recruited into a population-based case-control study of esophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow-up for all-cause mortality was 6.4 years. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pretreatment AJCC tumor stage, treatment and presence of comorbidities. Two hundred and thirteen patients (71%) died during follow-up. High lifetime alcohol consumption was independently associated with poor survival. Relative to life-long nondrinkers and those consuming

Original language	English
Pages (from-to)	E759-E768
Journal	International Journal of Cancer
Volume	131
Issue number	5
DOIs	https://doi.org/10.1002/ijc.27420
Publication status	Published - 1 Sept 2012

Keywords

Alcohol
Esophageal squamous cell carcinoma
Lifestyle factors
Survival
Tobacco smoking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.27420

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abstract = "Demographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of esophageal squamous cell carcinoma (ESCC); however, little is known about the effect of these factors on survival. We included all 301 patients with incident ESCC, recruited into a population-based case-control study of esophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow-up for all-cause mortality was 6.4 years. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pretreatment AJCC tumor stage, treatment and presence of comorbidities. Two hundred and thirteen patients (71%) died during follow-up. High lifetime alcohol consumption was independently associated with poor survival. Relative to life-long nondrinkers and those consuming",

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AU - Thrift, Aaron P.

AU - Nagle, Christina M.

AU - Fahey, Paul P.

AU - Russell, Anne

AU - Smithers, Bernard M.

AU - Watson, David I.

AU - Whiteman, David C.

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AB - Demographic and lifestyle factors, in particular tobacco smoking and alcohol, are well established causes of esophageal squamous cell carcinoma (ESCC); however, little is known about the effect of these factors on survival. We included all 301 patients with incident ESCC, recruited into a population-based case-control study of esophageal cancer in Australia. Detailed information about demographic and lifestyle factors was obtained at diagnosis, and deaths were identified using the National Death Index. Median follow-up for all-cause mortality was 6.4 years. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated from Cox proportional hazards models, adjusted for age, sex, pretreatment AJCC tumor stage, treatment and presence of comorbidities. Two hundred and thirteen patients (71%) died during follow-up. High lifetime alcohol consumption was independently associated with poor survival. Relative to life-long nondrinkers and those consuming

KW - Alcohol

KW - Esophageal squamous cell carcinoma

KW - Lifestyle factors

KW - Survival

KW - Tobacco smoking

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The influence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival

Abstract

Keywords

UN SDGs

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