The influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus).

FIJ Crawford; CL Hodgkinson; EA Ivanova; LB Logunova; GJ Evans; S Steinlechner; AS. Loudon

The influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus).

FIJ Crawford, CL Hodgkinson, EA Ivanova, LB Logunova, GJ Evans, S Steinlechner, AS. Loudon

Research output: Contribution to journal › Article › peer-review

Abstract

The Siberian hamster exhibits the key winter adaptive strategy of daily torpor, during which metabolism and heart rate are slowed for a few hours and body temperature declines by up to 20 degrees C, allowing substantial energetic savings. Previous studies of hibernators in which temperature drops by over 30 degrees C for many days to weeks have revealed decreased transcription and translation during hypometabolism, and identified several key physiological pathways involved. Here, we used a cDNA microarray to define cardiac transcript changes over the course of a daily torpor bout and return to normothermia, and show that in common with hibernators, a relatively small proportion of the transcriptome (

Original language	English
Journal	Physiol Genomics
Publication status	Published - 14 Nov 2007

Cite this

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title = "The influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus).",

abstract = "The Siberian hamster exhibits the key winter adaptive strategy of daily torpor, during which metabolism and heart rate are slowed for a few hours and body temperature declines by up to 20 degrees C, allowing substantial energetic savings. Previous studies of hibernators in which temperature drops by over 30 degrees C for many days to weeks have revealed decreased transcription and translation during hypometabolism, and identified several key physiological pathways involved. Here, we used a cDNA microarray to define cardiac transcript changes over the course of a daily torpor bout and return to normothermia, and show that in common with hibernators, a relatively small proportion of the transcriptome (",

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T1 - The influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus).

AU - Crawford, FIJ

AU - Hodgkinson, CL

AU - Ivanova, EA

AU - Logunova, LB

AU - Evans, GJ

AU - Steinlechner, S

AU - Loudon, AS.

PY - 2007/11/14

Y1 - 2007/11/14

N2 - The Siberian hamster exhibits the key winter adaptive strategy of daily torpor, during which metabolism and heart rate are slowed for a few hours and body temperature declines by up to 20 degrees C, allowing substantial energetic savings. Previous studies of hibernators in which temperature drops by over 30 degrees C for many days to weeks have revealed decreased transcription and translation during hypometabolism, and identified several key physiological pathways involved. Here, we used a cDNA microarray to define cardiac transcript changes over the course of a daily torpor bout and return to normothermia, and show that in common with hibernators, a relatively small proportion of the transcriptome (

AB - The Siberian hamster exhibits the key winter adaptive strategy of daily torpor, during which metabolism and heart rate are slowed for a few hours and body temperature declines by up to 20 degrees C, allowing substantial energetic savings. Previous studies of hibernators in which temperature drops by over 30 degrees C for many days to weeks have revealed decreased transcription and translation during hypometabolism, and identified several key physiological pathways involved. Here, we used a cDNA microarray to define cardiac transcript changes over the course of a daily torpor bout and return to normothermia, and show that in common with hibernators, a relatively small proportion of the transcriptome (

M3 - Article

SN - 1531-2267

JO - Physiol Genomics

JF - Physiol Genomics

ER -

The influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus).

Abstract

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