Abstract
Methanol is known for its toxicity to a wide range of micro-organisms. The presence of methanol in a system can significantly suppress microbial growth. In this paper, the growth of Cupriavidus necator DSM4058 in mineral medium containing methanol in a range 0-125. g/L is reported. It was found that methanol tested at any concentration had a negative influence on growth. However, the reduction in specific growth rate could be predicted by neither substrate nor product inhibition equations, and so a model, based on a saturation equation was developed and is presented here. The model is shown to fit particularly well, not only with the C. necator data but also with several sets of data extracted from publications based on other micro-organisms. It was found that the model successfully predicted the data with regression coefficients of over 96%, regardless of micro-organism or particular alcohol inhibitor. ?? 2015 Elsevier B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 84-90 |
| Journal | Biochemical Engineering Journal |
| Volume | 98 |
| DOIs | |
| Publication status | Published - 2015 |
Keywords
- Biology
- Fermentation
- Microorganisms
- Models
- Crude glycerol
- Cupriavidus necator
- Inhibition effect
- Microbial growth
- Product inhibition
- Regression coefficient
- Saturation equations
- Specific growth rate
- Methanol
- alcohol
- cell membrane protein
- glycerol
- methanol
- xylitol
- Article
- bacterial cell
- bacterial growth
- binding site
- Butyrivibrio fibrisolvens
- cell membrane
- continuous fermentation
- culture medium
- fungus growth
- growth inhibition
- growth rate
- Hill coefficient
- lipid composition
- Methylomonas methanica
- Meyerozyma guilliermondii
- microbial growth
- negative feedback
- nonhuman
- Ogataea angusta
- Prevotella ruminicola
- priority journal
- proton motive force
- receptor occupancy
- Saccharomyces cerevisiae
- Salmonella enterica subsp. enterica serovar Typhimurium
- Selenomonas ruminantium