The insulin-like growth factor system in the circulation of patients with viral infections

Ivona Baricevic-Jones, Ivona Baričević, Olgica Nedić, Judith Anna Nikolić, Jasminka Nedeljković

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    The insulin-like growth factor (IGF) system was examined in the circulation of patients with viral infections (herpes simplex virus, HSV; cytomegalovirus, CMV; rotavirus, RV and adenovirus, AV). The serum concentrations of IGF-I, IGF-II and cortisol were measured by radioimmunoassay, while IGF-binding proteins (IGFBPs) were characterised by ligand-affinity blotting. Although both IGF-I and IGF-II concentrations were significantly lower in patients with viral infections (p <0.05) than in healthy persons, the IGF-II/IGF-I ratio was increased (p <0.05). No correlation between the concentration of IGF-I and IGF-II and the intensity of the antibody response to infection was observed. Ligand-affinity blotting demonstrated decreased amounts of IGFBP-3 (patients with HSV, CMV, AV and some patients with RV), increased IGFBP-2 (some patients with HSV and RV) and IGFBP-1 (patients with RV). Serum cortisol was significantly elevated (p <0.05) in patients infected with HSV, CMV and RV. The alterations observed can be interpreted as induction of the hypothalamic-pituitary-adrenal axis and suppression of the growth hormone (GH)/IGF axis under the influence of viral infection. © 2004 by Walter de Gruyter.
    Original languageEnglish
    Pages (from-to)1127-1131
    Number of pages4
    JournalClinical Chemistry and Laboratory Medicine
    Issue number10
    Publication statusPublished - 2004


    • Adenovirus
    • Cortisol
    • Cytomegalovirus
    • Herpes simplex virus
    • Insulin-like growth factor
    • Insulin-like growth factor-binding protein
    • Rotavirus


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