The interaction between bronchoconstriction and cough in asthma

Imran Satia; Huda Badri; Mark Woodhead; Paul M O'Byrne; Stephen J Fowler; Jaclyn A Smith

doi:10.1136/thoraxjnl-2016-209625

The interaction between bronchoconstriction and cough in asthma

Imran Satia, Huda Badri, Mark Woodhead, Paul M O'Byrne, Stephen J Fowler, Jaclyn A Smith

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Abstract

Variable airflow obstruction is a pathophysiological hallmark of asthma; however, the interactions between acute bronchoconstriction and the cough reflex are poorly understood. We performed a randomised, single-blind, placebo-controlled, crossover study to investigate the interaction between bronchoconstriction and cough in asthma. Capsaicin was administered to evoke coughs and methacholine to induce bronchoconstriction. We demonstrated that acute bronchoconstriction increased capsaicin-evoked coughs, which improved as airway calibre spontaneously resolved. However, capsaicin-evoked coughing had no impact on methacholine-induced bronchoconstriction. This study provides evidence that bronchoconstriction increases the activation of capsaicin-responsive airway nerves, but the precise mechanisms and mediators involved require further evaluation.

TRIAL REGISTRATION NUMBER: ISRCTN14900082.

Original language	English
Journal	Thorax
Early online date	24 Feb 2017
DOIs	https://doi.org/10.1136/thoraxjnl-2016-209625
Publication status	Published - 2017

Keywords

Letter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/thoraxjnl-2016-209625

Beach Letter THORAX 061216Accepted author manuscript, 53.5 KB

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title = "The interaction between bronchoconstriction and cough in asthma",

abstract = "Variable airflow obstruction is a pathophysiological hallmark of asthma; however, the interactions between acute bronchoconstriction and the cough reflex are poorly understood. We performed a randomised, single-blind, placebo-controlled, crossover study to investigate the interaction between bronchoconstriction and cough in asthma. Capsaicin was administered to evoke coughs and methacholine to induce bronchoconstriction. We demonstrated that acute bronchoconstriction increased capsaicin-evoked coughs, which improved as airway calibre spontaneously resolved. However, capsaicin-evoked coughing had no impact on methacholine-induced bronchoconstriction. This study provides evidence that bronchoconstriction increases the activation of capsaicin-responsive airway nerves, but the precise mechanisms and mediators involved require further evaluation.TRIAL REGISTRATION NUMBER: ISRCTN14900082.",

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author = "Imran Satia and Huda Badri and Mark Woodhead and O'Byrne, {Paul M} and Fowler, {Stephen J} and Smith, {Jaclyn A}",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.",

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language = "English",

journal = "Thorax",

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TY - JOUR

T1 - The interaction between bronchoconstriction and cough in asthma

AU - Satia, Imran

AU - Badri, Huda

AU - Woodhead, Mark

AU - O'Byrne, Paul M

AU - Fowler, Stephen J

AU - Smith, Jaclyn A

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

PY - 2017

Y1 - 2017

N2 - Variable airflow obstruction is a pathophysiological hallmark of asthma; however, the interactions between acute bronchoconstriction and the cough reflex are poorly understood. We performed a randomised, single-blind, placebo-controlled, crossover study to investigate the interaction between bronchoconstriction and cough in asthma. Capsaicin was administered to evoke coughs and methacholine to induce bronchoconstriction. We demonstrated that acute bronchoconstriction increased capsaicin-evoked coughs, which improved as airway calibre spontaneously resolved. However, capsaicin-evoked coughing had no impact on methacholine-induced bronchoconstriction. This study provides evidence that bronchoconstriction increases the activation of capsaicin-responsive airway nerves, but the precise mechanisms and mediators involved require further evaluation.TRIAL REGISTRATION NUMBER: ISRCTN14900082.

AB - Variable airflow obstruction is a pathophysiological hallmark of asthma; however, the interactions between acute bronchoconstriction and the cough reflex are poorly understood. We performed a randomised, single-blind, placebo-controlled, crossover study to investigate the interaction between bronchoconstriction and cough in asthma. Capsaicin was administered to evoke coughs and methacholine to induce bronchoconstriction. We demonstrated that acute bronchoconstriction increased capsaicin-evoked coughs, which improved as airway calibre spontaneously resolved. However, capsaicin-evoked coughing had no impact on methacholine-induced bronchoconstriction. This study provides evidence that bronchoconstriction increases the activation of capsaicin-responsive airway nerves, but the precise mechanisms and mediators involved require further evaluation.TRIAL REGISTRATION NUMBER: ISRCTN14900082.

KW - Letter

U2 - 10.1136/thoraxjnl-2016-209625

DO - 10.1136/thoraxjnl-2016-209625

M3 - Article

C2 - 28235887

SN - 0040-6376

JO - Thorax

JF - Thorax

ER -

The interaction between bronchoconstriction and cough in asthma

Abstract

Keywords

UN SDGs

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