The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

Derek Sharples; Gabriella Spengler; Joseph Molnár; Zsuzsanna Antal; Annamária Molnár; János T. Kiss; József A. Szabó; Andreas Hilgeroth; Sandrine Gallo; Abdallah Mahamoud; Jacques Barbe

doi:10.1016/j.ejmech.2004.10.011

The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

Derek Sharples, Gabriella Spengler, Joseph Molnár, Zsuzsanna Antal, Annamária Molnár, János T. Kiss, József A. Szabó, Andreas Hilgeroth, Sandrine Gallo, Abdallah Mahamoud, Jacques Barbe

Research output: Contribution to journal › Article › peer-review

Abstract

Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers. © 2005 Elsevier SAS. All rights reserved.

Original language	English
Pages (from-to)	195-202
Number of pages	7
Journal	European Journal of Medicinal Chemistry
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.ejmech.2004.10.011
Publication status	Published - Feb 2005

Keywords

Aza-fluorenes
DNA interaction
MDR1 p-glycoprotein
Pregnanes
Pyridoquinolines
Transfer RNA interaction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2004.10.011

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Sharples, D., Spengler, G., Molnár, J., Antal, Z., Molnár, A., Kiss, J. T., Szabó, J. A., Hilgeroth, A., Gallo, S., Mahamoud, A., & Barbe, J. (2005). The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA. European Journal of Medicinal Chemistry, 40(2), 195-202. https://doi.org/10.1016/j.ejmech.2004.10.011

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title = "The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA",

abstract = "Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers. {\textcopyright} 2005 Elsevier SAS. All rights reserved.",

keywords = "Aza-fluorenes, DNA interaction, MDR1 p-glycoprotein, Pregnanes, Pyridoquinolines, Transfer RNA interaction",

author = "Derek Sharples and Gabriella Spengler and Joseph Moln{\'a}r and Zsuzsanna Antal and Annam{\'a}ria Moln{\'a}r and Kiss, {J{\'a}nos T.} and Szab{\'o}, {J{\'o}zsef A.} and Andreas Hilgeroth and Sandrine Gallo and Abdallah Mahamoud and Jacques Barbe",

year = "2005",

month = feb,

doi = "10.1016/j.ejmech.2004.10.011",

language = "English",

volume = "40",

pages = "195--202",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "2",

}

Sharples, D, Spengler, G, Molnár, J, Antal, Z, Molnár, A, Kiss, JT, Szabó, JA, Hilgeroth, A, Gallo, S, Mahamoud, A & Barbe, J 2005, 'The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA', European Journal of Medicinal Chemistry, vol. 40, no. 2, pp. 195-202. https://doi.org/10.1016/j.ejmech.2004.10.011

TY - JOUR

T1 - The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

AU - Sharples, Derek

AU - Spengler, Gabriella

AU - Molnár, Joseph

AU - Antal, Zsuzsanna

AU - Molnár, Annamária

AU - Kiss, János T.

AU - Szabó, József A.

AU - Hilgeroth, Andreas

AU - Gallo, Sandrine

AU - Mahamoud, Abdallah

AU - Barbe, Jacques

PY - 2005/2

Y1 - 2005/2

N2 - Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers. © 2005 Elsevier SAS. All rights reserved.

AB - Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers. © 2005 Elsevier SAS. All rights reserved.

KW - Aza-fluorenes

KW - DNA interaction

KW - MDR1 p-glycoprotein

KW - Pregnanes

KW - Pyridoquinolines

KW - Transfer RNA interaction

U2 - 10.1016/j.ejmech.2004.10.011

DO - 10.1016/j.ejmech.2004.10.011

M3 - Article

SN - 0223-5234

VL - 40

SP - 195

EP - 202

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 2

ER -

The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

Abstract

Keywords

UN SDGs

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