The INTEROCC case-control study: Risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents

Damien Mcelvenny, Martie Van Tongeren, Michelle C Turner, Geza Benke, Jordi Figuerola, Sarah Fleming, Martine Hours, Laurel Kincl, Dave McLean, Marie-Elise Parent, Lesley Richardson, Brigitte Schlehofer, Klaus Schlaefer, Siegal Sadetzki, Joachim Schüz, Jack Siemiatycki, Elisabeth Cardis

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Abstract

Background
Little is known about occupational risk factors for meningioma.
Objectives
To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents.
Methods
The INTEROCC was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure for the 12 agents. Odds ratios for ever versus never exposed and for exposure-response using duration of exposure and cumulative exposure were derived using conditional logistic regression stratified by sex, age group, country/region, adjusted for education.
Results
These analyses included 1,906 cases and 5,565 controls. For 11 of the 12 agents, no excess risk was found for ever exposed. For ever exposure to oil mists, an elevated OR of 1.57 (95% CI 1.10 to 2.22, 51 exposed cases) was found. Statistically significant exposure-response relationships were observed with cumulative exposure (p-trend=0.01) and duration of exposure (p-trend=0.04). Among women, there were also significant trends for cumulative and duration of exposure to asbestos and excesses in the highest exposure categories for formaldehyde.
Conclusions
Most agents examined did not provoke excess risks of meningioma. The main finding from this study is that it is the first study to identify a statistical association between exposure to oil mists and meningioma. This may be a chance finding or could be due to confounding with iron exposure and further research is required to understand whether the relationship is causal.
Original languageEnglish
JournalOccupational and Environmental Medicine
Early online date25 Sept 2017
DOIs
Publication statusPublished - 2017

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