The JIP1 Scaffold Protein Regulates Axonal Development in Cortical Neurons

Federico Dajas-Bailador, Emma V. Jones, Alan J. Whitmarsh

    Research output: Contribution to journalArticlepeer-review


    The development of neuronal polarity is essential for the determination of neuron connectivity and for correct brain function. The c-Jun N-terminal kinase (JNK)-interacting protein-1 (JIP1) is highly expressed in neurons and has previously been characterized as a regulator of JNK signaling. JIP1 has been shown to localize to neurites in various neuronal models, but the functional significance of this localization is not fully understood [1-4]. JIP1 is also a cargo of the motor protein kinesin-1, which is important for axonal transport [2, 4]. Here we demonstrate that before primary cortical neurons become polarized, JIP1 specifically localizes to a single neurite and that after axonal specification, it accumulates in the emerging axon. JIP1 is necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the c-Abl tyrosine kinase. JIP1 associates with and is phosphorylated by c-Abl, and the mutation of the c-Abl phosphorylation site on JIP1 abrogates its ability to promote axonal growth. JIP1 is therefore an important regulator of axonal development and is a key target of c-Abl-dependent pathways that control axonal growth. © 2008 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)221-226
    Number of pages5
    JournalCurrent Biology
    Issue number3
    Publication statusPublished - 12 Feb 2008




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