The local lymph node assay: Developments and applications

I. Kimber; R. J. Dearman; E. W. Scholes; D. A. Basketter

doi:10.1016/0300-483X(94)90193-7

The local lymph node assay: Developments and applications

I. Kimber, R. J. Dearman, E. W. Scholes, D. A. Basketter

Research output: Contribution to journal › Article › peer-review

Abstract

The murine local lymph node assay is a predictive test method for the identification of contact allergens in which sensitizing activity is measured as a function of induced proliferative responses in lymph nodes draining the site of application. In this article the development and validation of the assay are described and comparisons with guinea pig predictive test methods discussed, In addition we examine the advantages and limitations of the method and consider new opportunities and applications of the assay in the context of the toxicological evaluation of sensitizing potential.

Original language	English
Pages (from-to)	13-31
Number of pages	18
Journal	Toxicology
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/0300-483X(94)90193-7
Publication status	Published - 1994

Keywords

Contact sensitization
Local lymph node assay
Predictive testing

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10.1016/0300-483X(94)90193-7

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title = "The local lymph node assay: Developments and applications",

abstract = "The murine local lymph node assay is a predictive test method for the identification of contact allergens in which sensitizing activity is measured as a function of induced proliferative responses in lymph nodes draining the site of application. In this article the development and validation of the assay are described and comparisons with guinea pig predictive test methods discussed, In addition we examine the advantages and limitations of the method and consider new opportunities and applications of the assay in the context of the toxicological evaluation of sensitizing potential.",

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author = "I. Kimber and Dearman, {R. J.} and Scholes, {E. W.} and Basketter, {D. A.}",

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AU - Basketter, D. A.

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AB - The murine local lymph node assay is a predictive test method for the identification of contact allergens in which sensitizing activity is measured as a function of induced proliferative responses in lymph nodes draining the site of application. In this article the development and validation of the assay are described and comparisons with guinea pig predictive test methods discussed, In addition we examine the advantages and limitations of the method and consider new opportunities and applications of the assay in the context of the toxicological evaluation of sensitizing potential.

KW - Contact sensitization

KW - Local lymph node assay

KW - Predictive testing

U2 - 10.1016/0300-483X(94)90193-7

DO - 10.1016/0300-483X(94)90193-7

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SP - 13

EP - 31

JO - Toxicology

JF - Toxicology

SN - 1879-3185

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The local lymph node assay: Developments and applications

Abstract

Keywords

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