The Magpie Trial: A randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months

L. Duley, Barbara Farrell, Nina Armstrong, Patsy Spark, Barbara Roberts, Rebecca Smyth, Mary Tivnan, Anna Laws, Noelene Corfield, Annette Salter, Lisa Thorn, Douglas Altman, Ly Mee Yu, Edgardo Abalos, Berenise Carroli, Lucrecia Dellepiane, Marina Duarte, Hebe Fernandez, Daniel Giordano, Mike ClarkeAlastair Gray, Edmund Hey, James Neilson, Judit Simon, Lex Doyle, Tom Kelly, Jane Squires, Rory Collins, Anna Karaoglou, Richard Lilford, Stephen Robson, Ian Roberts, Peter Rubin, James Thornton, Sara Twaddle, José Villar, Isabel Walker, Christopher Watkins, A. Bimbashi, E. Demalia, O. Gliozheni, A. Shpata, A. Karolinski, M. Lamas, M. Pesaresi, V. Wainer, W. Barbato, M. Paciocco, M. Bertin, E. Boiza, J. Castaldi, Y. Partida, C. Arias, M. Farri, G. Kerz, J. Aguirre, M. De Sagastizábal, R. Falcone, E. Morales, G. Carroli, S. Krupitzky, S. López, M. Palermo, D. Montes Varela, H. Delprato, H. Camusso, M. Curioni, E. Ludmer, R. Brandi, R. Martin, W. Mesas, R. Taralli, M. Lezaola, M. Morosini, E. Andina, L. Bernal, M. Estiú, E. Ulens, B. Ortiz De Speranza, A. Peyrano, M. Damiano, C. Saumench, J. Horn, M. Pritchard, V. Smith-Orr, M. Wilson, A. Lawrence, D. Watson, C. Crowther, J. Paynter, [Unknown] Ashrafunnessa, M. Mannan, M. Shahidullah, L. Shamsuddin, C. Barros Santos, S. Freire, E. Melo, E. Cobo, E. Jaramillo, C. Cardozo, N. Fandiño, H. Gaitán, L. Montaño, J. Lozano, M. Rojas, A. Breto Garcíá, A. Fuentes Ramirez, R. Garcíá Mírás, S. Sampera, U. Farnot, E. Gómez, G. Rojas, R. Valdés, H. Abd El-Kreem, T. Al-Hussaini, E. Hammad, K. Danso, E. Kwapong, E. Ofosu-Barko, M. Padmini Jasper, A. Peedicayil, A. Regi, R. Sharma, A. Chauhan, V. Raut, R. Udani, S. Batra, A. Muthal-Rathore, S. Ramji, V. Zutshi, S. Balakrishnan, E. Eapen, G. Koshy, N. Ambardar, P. Vadakkepat, D. Vaidya, V. Lema, Y. Rijken, E. Tadesse, O. Dada, A. Sofekun, C. Ohiaeri, T. Runsewe-Abiodun, I. Adewole, A. Adeyemo, B. Brown, R. Oladokun, O. Adewale, N. Inimgba, C. John, R. Ogu, B. Ekele, A. Isah, B. Onankpa, R. Jamelle, D. Junejo, N. Ruby Faiz, F. Gul, A. Sherin, K. Bangash, G. Mahmud, K. Masud, N. Tasneem, S. Gassama, A. Soyei, P. Agarwal, V. Rajadurai, N. Pirani, S. Delport, P. Macdonald, R. Mokhondo, R. Pattinson, M. Zondo, M. Adhikari, N. Mnguni, J. Moodley, M. Carstens, G. Kirsten, W. Steyn, J. Van Zyl, A. Helwig, S. L. Jacobson, R. Panosche, E. Hammond, L. Masanganise

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: To assess the long-term effects of in utero exposure to magnesium sulphate for children whose mothers had pre-eclampsia. Design: Assessment at 18 months of age for children whose mothers were recruited to the Magpie Trial (recruitment 1998-2001 ISRCTN 86938761), which compared magnesium sulphate with placebo. Setting: Follow-up of children born at 125 centres in 19 countries across five continents. Population: A total of 6922 children were born to women randomised before delivery at follow-up centres. Of these, 2271 were not included for logistic reasons and 168 were excluded (101 at a centre where
    Original languageEnglish
    Pages (from-to)289-299
    Number of pages10
    JournalBJOG: An International Journal of Obstetrics and Gynaecology
    Volume114
    Issue number3
    DOIs
    Publication statusPublished - Mar 2007

    Keywords

    • Longterm follow-up
    • Magnesium sulphate
    • Pre-eclampsia
    • Randomised trial

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