The microbiology of asthma

Michael R. Edwards, Nathan W. Bartlett, Tracy Hussell, Peter Openshaw, Sebastian L. Johnston

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Asthma remains an important human disease that is responsible for substantial worldwide morbidity and mortality. The causes of asthma are multifactorial and include a complex mix of environmental, immunological and host genetic factors. In addition, epidemiological studies show strong associations between asthma and infection with respiratory pathogens, including common respiratory viruses such as rhinoviruses, human respiratory syncytial virus, adenoviruses, coronaviruses and influenza viruses, as well as bacteria (including atypical bacteria) and fungi. In this Review, we describe the many roles of microorganisms in the risk of developing asthma and in the pathogenesis of and protection against the disease, and we discuss the mechanisms by which infections affect the severity and prevalence of asthma. © 2012 Macmillan Publishers Limited. All rights reserved.
    Original languageEnglish
    Pages (from-to)459-471
    Number of pages12
    JournalNature Reviews Microbiology
    Volume10
    Issue number7
    DOIs
    Publication statusPublished - Jul 2012

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