The molecular characterization of the fetal stem cell marker AA4

Oleksi Petrenko; Andrew Beavis; Michele Klaine; Raja Kittappa; Isabelle Godin; Ihor R. Lemischka

doi:10.1016/S1074-7613(00)80068-0

The molecular characterization of the fetal stem cell marker AA4

Oleksi Petrenko, Andrew Beavis, Michele Klaine, Raja Kittappa, Isabelle Godin, Ihor R. Lemischka

Research output: Contribution to journal › Article › peer-review

Abstract

We have identified and characterized the stem cell antigen AA4. This molecule is a type I transmembrane protein whose overall structure suggests a role in cell adhesion. During fetal ontogeny (days 9-14 of development), AA4 is expressed in three major cell types: vascular endothelial cells, aorta- associated hematopoietic clusters, and primitive fetal liver hematopoietic progenitors. In the adult, AA4 is abundant in lung, heart, and whole bone marrow. In the adult hematopoietic compartment, aa4 transcripts are present in bone marrow CD34(-/lo)Lin-Sca-1+c-Kit+ and CD34(hi) Lin-Sca-1+c-Kit+ stem and progenitor cell subsets. Our observations suggest that AA4 plays a role in cell-cell interactions during hematopoietic and vascular development.

Original language	English
Pages (from-to)	691-700
Number of pages	9
Journal	Immunity
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/S1074-7613(00)80068-0
Publication status	Published - Jun 1999

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title = "The molecular characterization of the fetal stem cell marker AA4",

abstract = "We have identified and characterized the stem cell antigen AA4. This molecule is a type I transmembrane protein whose overall structure suggests a role in cell adhesion. During fetal ontogeny (days 9-14 of development), AA4 is expressed in three major cell types: vascular endothelial cells, aorta- associated hematopoietic clusters, and primitive fetal liver hematopoietic progenitors. In the adult, AA4 is abundant in lung, heart, and whole bone marrow. In the adult hematopoietic compartment, aa4 transcripts are present in bone marrow CD34(-/lo)Lin-Sca-1+c-Kit+ and CD34(hi) Lin-Sca-1+c-Kit+ stem and progenitor cell subsets. Our observations suggest that AA4 plays a role in cell-cell interactions during hematopoietic and vascular development.",

author = "Oleksi Petrenko and Andrew Beavis and Michele Klaine and Raja Kittappa and Isabelle Godin and Lemischka, {Ihor R.}",

note = "R01 CA 45339, NCI NIH HHS, United StatesR01 DK 42989, NIDDK NIH HHS, United States",

year = "1999",

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doi = "10.1016/S1074-7613(00)80068-0",

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AU - Petrenko, Oleksi

AU - Beavis, Andrew

AU - Klaine, Michele

AU - Kittappa, Raja

AU - Godin, Isabelle

AU - Lemischka, Ihor R.

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AB - We have identified and characterized the stem cell antigen AA4. This molecule is a type I transmembrane protein whose overall structure suggests a role in cell adhesion. During fetal ontogeny (days 9-14 of development), AA4 is expressed in three major cell types: vascular endothelial cells, aorta- associated hematopoietic clusters, and primitive fetal liver hematopoietic progenitors. In the adult, AA4 is abundant in lung, heart, and whole bone marrow. In the adult hematopoietic compartment, aa4 transcripts are present in bone marrow CD34(-/lo)Lin-Sca-1+c-Kit+ and CD34(hi) Lin-Sca-1+c-Kit+ stem and progenitor cell subsets. Our observations suggest that AA4 plays a role in cell-cell interactions during hematopoietic and vascular development.

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DO - 10.1016/S1074-7613(00)80068-0

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SN - 1074-7613

VL - 10

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EP - 700

JO - Immunity

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ER -

The molecular characterization of the fetal stem cell marker AA4

Abstract

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