The Netherlands study of depression in older persons (NESDO); a prospective cohort study.

Hannie C Comijs, Harm Van Marwijk, Roos C {Van Der Mast}, Paul Naarding, Richard C {Oude Voshaar}, Aartjan Tf Beekman, Marjolein Boshuisen, Janny Dekker, Rob Kok, Margot Wm {De Waal}, Brenda Wjh Penninx, Max L Stek, Johannes H Smit

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    ABSTRACT: BACKGROUND: We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. METHODS: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (greater than or equal to 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. RESULTS: The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95{\%} had a major depression and 26.5{\%} had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1{\%} of the depressed persons it was their first episode. 41.0{\%} of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. CONCLUSIONS: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons.
    Original languageEnglish
    JournalBMC Research Notes
    Publication statusPublished - 2011


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