The new immunosuppression: Intervention at the dendritic cell-T-cell interface

Alison M. Paterson, S. F. Yates, K. F. Nolan, H. Waldmann

    Research output: Contribution to journalArticlepeer-review


    Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function. © 2005 Bentham Science Publishers Ltd.
    Original languageEnglish
    Pages (from-to)397-411
    Number of pages14
    JournalCurrent Drug Targets: Immune, Endocrine and Metabolic Disorders
    Issue number4
    Publication statusPublished - Dec 2005


    • Antibodies
    • Dendritic cells
    • Immunological synapse
    • Pharmacological agents
    • T cells
    • Tolerance


    Dive into the research topics of 'The new immunosuppression: Intervention at the dendritic cell-T-cell interface'. Together they form a unique fingerprint.

    Cite this