The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Jaclyn Smith; Lesley A. Houghton

doi:10.1186/1745-9974-9-12

The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Jaclyn Smith, Lesley A. Houghton

Research output: Contribution to journal › Article › peer-review

Abstract

Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. © 2013 Smith and Houghton; licensee BioMed Central Ltd.

Original language	English
Article number	12
Journal	Cough
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1745-9974-9-12
Publication status	Published - 2013

Access to Document

10.1186/1745-9974-9-12

http://www.coughjournal.com/content/9/1/12

Cite this

@article{4d089aa6b42749ddab0ea09d9eb62016,

title = "The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes",

abstract = "Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. {\textcopyright} 2013 Smith and Houghton; licensee BioMed Central Ltd.",

author = "Jaclyn Smith and Houghton, {Lesley A.}",

year = "2013",

doi = "10.1186/1745-9974-9-12",

language = "English",

volume = "9",

journal = "Cough",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes

AU - Smith, Jaclyn

AU - Houghton, Lesley A.

PY - 2013

Y1 - 2013

N2 - Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. © 2013 Smith and Houghton; licensee BioMed Central Ltd.

AB - Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed. © 2013 Smith and Houghton; licensee BioMed Central Ltd.

U2 - 10.1186/1745-9974-9-12

DO - 10.1186/1745-9974-9-12

M3 - Article

VL - 9

JO - Cough

JF - Cough

IS - 1

M1 - 12

ER -

The oesophagus and cough: Laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Abstract

Access to Document

Fingerprint

Cite this