The oncogenic potential of Candida in the female genital tract

C. J N Lacey; S. Dutton; R. A. Smith; R. M. Walmsley; B. M. Wilkinson; E. G V Evans; C. A. Hitchcock; D. J. Adams

doi:10.1046/j.1525-1438.1995.05010008.x

The oncogenic potential of Candida in the female genital tract

C. J N Lacey, S. Dutton, R. A. Smith, R. M. Walmsley, B. M. Wilkinson, E. G V Evans, C. A. Hitchcock, D. J. Adams

Research output: Contribution to journal › Article › peer-review

Abstract

The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.

Original language	English
Pages (from-to)	8-14
Number of pages	6
Journal	International Journal of Gynecological Cancer
Volume	5
Issue number	1
DOIs	https://doi.org/10.1046/j.1525-1438.1995.05010008.x
Publication status	Published - 1995

Keywords

Candida
CIN
nitrosamines
oncogenesis
restriction fragment length polymorphisms

Access to Document

10.1046/j.1525-1438.1995.05010008.x

Cite this

@article{533ecfe2f0dc481b8a72f6e5e99e0e76,

title = "The oncogenic potential of Candida in the female genital tract",

abstract = "The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.",

keywords = "Candida, CIN, nitrosamines, oncogenesis, restriction fragment length polymorphisms",

author = "Lacey, {C. J N} and S. Dutton and Smith, {R. A.} and Walmsley, {R. M.} and Wilkinson, {B. M.} and Evans, {E. G V} and Hitchcock, {C. A.} and Adams, {D. J.}",

year = "1995",

doi = "10.1046/j.1525-1438.1995.05010008.x",

language = "English",

volume = "5",

pages = "8--14",

journal = "International Journal of Gynecological Cancer",

issn = "1525-1438",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - The oncogenic potential of Candida in the female genital tract

AU - Lacey, C. J N

AU - Dutton, S.

AU - Smith, R. A.

AU - Walmsley, R. M.

AU - Wilkinson, B. M.

AU - Evans, E. G V

AU - Hitchcock, C. A.

AU - Adams, D. J.

PY - 1995

Y1 - 1995

N2 - The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.

AB - The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.

KW - Candida

KW - CIN

KW - nitrosamines

KW - oncogenesis

KW - restriction fragment length polymorphisms

U2 - 10.1046/j.1525-1438.1995.05010008.x

DO - 10.1046/j.1525-1438.1995.05010008.x

M3 - Article

C2 - 11578446

SN - 1525-1438

VL - 5

SP - 8

EP - 14

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

IS - 1

ER -

The oncogenic potential of Candida in the female genital tract

Abstract

Keywords

Access to Document

Fingerprint

Cite this