The oncogenic potential of the high mobility group box protein Sox3

Y. Xia; N. Papalopulu; P. K. Vogt; J. Li

The oncogenic potential of the high mobility group box protein Sox3

Y. Xia, N. Papalopulu, P. K. Vogt, J. Li

Research output: Contribution to journal › Article › peer-review

Abstract

Sox proteins belong to the superfamily of high mobility group (HMG) proteins. Sox3 is expressed predominantly in the immature neuroepithelium. Ectopic expression of Sox3 causes oncogenic transformation of chicken embryo fibroblasts (CEFs). The oncogenicity of Sox3 is correlated with nuclear localization and transcriptional regulatory activity; mutants containing deletions in the HMG box or the transactivation domain fail to induce loci of transformation. These observations suggest that Sox proteins can induce aberrant cell growth and strengthen the link of HMG proteins to oncogenesis.

Original language	English
Pages (from-to)	6303-6306
Number of pages	3
Journal	Cancer Research
Volume	60
Issue number	22
Publication status	Published - 2000

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title = "The oncogenic potential of the high mobility group box protein Sox3",

abstract = "Sox proteins belong to the superfamily of high mobility group (HMG) proteins. Sox3 is expressed predominantly in the immature neuroepithelium. Ectopic expression of Sox3 causes oncogenic transformation of chicken embryo fibroblasts (CEFs). The oncogenicity of Sox3 is correlated with nuclear localization and transcriptional regulatory activity; mutants containing deletions in the HMG box or the transactivation domain fail to induce loci of transformation. These observations suggest that Sox proteins can induce aberrant cell growth and strengthen the link of HMG proteins to oncogenesis.",

author = "Y. Xia and N. Papalopulu and Vogt, {P. K.} and J. Li",

year = "2000",

language = "English",

volume = "60",

pages = "6303--6306",

journal = "Cancer Research",

issn = "1538-7445",

publisher = "American Association for Cancer Research",

number = "22",

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T1 - The oncogenic potential of the high mobility group box protein Sox3

AU - Xia, Y.

AU - Papalopulu, N.

AU - Vogt, P. K.

AU - Li, J.

PY - 2000

Y1 - 2000

N2 - Sox proteins belong to the superfamily of high mobility group (HMG) proteins. Sox3 is expressed predominantly in the immature neuroepithelium. Ectopic expression of Sox3 causes oncogenic transformation of chicken embryo fibroblasts (CEFs). The oncogenicity of Sox3 is correlated with nuclear localization and transcriptional regulatory activity; mutants containing deletions in the HMG box or the transactivation domain fail to induce loci of transformation. These observations suggest that Sox proteins can induce aberrant cell growth and strengthen the link of HMG proteins to oncogenesis.

AB - Sox proteins belong to the superfamily of high mobility group (HMG) proteins. Sox3 is expressed predominantly in the immature neuroepithelium. Ectopic expression of Sox3 causes oncogenic transformation of chicken embryo fibroblasts (CEFs). The oncogenicity of Sox3 is correlated with nuclear localization and transcriptional regulatory activity; mutants containing deletions in the HMG box or the transactivation domain fail to induce loci of transformation. These observations suggest that Sox proteins can induce aberrant cell growth and strengthen the link of HMG proteins to oncogenesis.

M3 - Article

SN - 1538-7445

VL - 60

SP - 6303

EP - 6306

JO - Cancer Research

JF - Cancer Research

IS - 22

ER -

The oncogenic potential of the high mobility group box protein Sox3

Abstract

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