The optimal length of 'coasting protocol' in women at risk of ovarian hyperstimulation syndrome undergoing in vitro fertilization

Luciano G. Nardo, Priya Cheema, Tarek A. Gelbaya, Greg Horne, Cheryl T. Fitzgerald, Elizabeth H E Pease, Daniel R. Brison, Brian A. Lieberman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially life-threatening complication following ovarian stimulation for in vitro fertilization (IVF). Coasting is the practice whereby the gonadotrophins are withheld and the administration of human chorionic gonadotrophin (hCG) is delayed until serum oestradiol (E2) has decreased to what is considered to be a safe level, to prevent the onset of OHSS. This study aimed to assess the length of coasting on the reproductive outcome in women at risk of developing OHSS. Coasting was undertaken when the serum E2 concentrations were ≥7000 pmol/L but
    Original languageEnglish
    Pages (from-to)175-180
    Number of pages5
    JournalHuman Fertility
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - Sept 2006

    Keywords

    • Coasting
    • IVF
    • OHSS
    • Ovarian stimulation
    • Pregnancy and live birth rates
    • Reproductive outcome

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