Abstract
Systemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms. Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis. The outcome of SSc is not as bleak as it looked a couple of decades ago. With a greater understanding of older pathways, as well as elucidation of newer ones, the potential targets to block and even reverse fibrosis bring around a revolution in the way we look at this once dreaded disease.
Original language | English |
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Pages (from-to) | S142-S148 |
Number of pages | 7 |
Journal | Indian Journal of Rheumatology |
Volume | 12 |
Issue number | 6 |
Publication status | Published - 1 Nov 2017 |
Keywords
- Endothelial dysfunction
- Endothelial progenitor cells
- Endothelial to mesenchymal transition
- Fibrosis
- Hypoxia
- Serotonin
- Transforming growth factor-beta