The pathogenesis of scleroderma

L. Gupta, S. Ahmed, A. Zanwar

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms. Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis. The outcome of SSc is not as bleak as it looked a couple of decades ago. With a greater understanding of older pathways, as well as elucidation of newer ones, the potential targets to block and even reverse fibrosis bring around a revolution in the way we look at this once dreaded disease.
Original languageEnglish
Pages (from-to)S142-S148
Number of pages7
JournalIndian Journal of Rheumatology
Volume12
Issue number6
Publication statusPublished - 1 Nov 2017

Keywords

  • Endothelial dysfunction
  • Endothelial progenitor cells
  • Endothelial to mesenchymal transition
  • Fibrosis
  • Hypoxia
  • Serotonin
  • Transforming growth factor-beta

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