Abstract
Idiopathic inflammatory myopathy (IIM) is a term used for a heterogeneous group of diseases characterized by severe muscle weakness. In addition to pharmacological treatment options, non-pharmacological methods such as exercising are essential for proper management of myositis. The present article aimed to provide an insight into the potential pathophysiological mechanisms underlying exercise-related benefits in myositis. A systematic search was performed on PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar using the following keywords and their combinations: "idiopathic inflammatory myopathy", "inflammatory myopathy", "myositis", "polymyositis", "dermatomyositis", "inclusion body myositis", and "exercise". Current literature indicates that exercising has impact on both immune and non-immune pathways in patients with IIM. Exercise-related benefits include (a) increased mitochondrial biogenesis/enzyme activity, (b) reconditioning of immune/inflammatory pathways, (c) decreased endoplasmic reticulum stress, (d) modulation of gene expression, (e) increased protein synthesis and cytoskeletal remodeling, and (f) decreased muscle fibrosis and non-muscle area infiltrates. With its certain benefits, exercise stands as a precious non-pharmacological treatment option for patients with IIM.
| Original language | English |
|---|---|
| Pages (from-to) | 896-903 |
| Number of pages | 8 |
| Journal | International Journal of Rheumatic Diseases |
| Volume | 24 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2021 |
Keywords
- Angiogenesis Inducing Agents
- Endoplasmic Reticulum Stress
- Exercise/physiology
- Exercise Therapy
- Humans
- Muscle, Skeletal/physiopathology
- Myositis/therapy
- Reactive Oxygen Species
- Resistance Training
- Severity of Illness Index
- Treatment Outcome