The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate

Heike Lorenz; Jan Von Langermann; Ghazla Sadiq; Colin C. Seaon; Roger J. Davey; Andreas Seidel-Morgenstern

doi:10.1021/cg1015077

The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate

Heike Lorenz, Jan Von Langermann, Ghazla Sadiq, Colin C. Seaon, Roger J. Davey, Andreas Seidel-Morgenstern

Research output: Contribution to journal › Article › peer-review

Abstract

Crystallization of racemic 2-chloromandelic acid yields a metastable conglomerate in addition to a more stable racemic compound. The crystal structure of the pure enantiomer is reported and the relative stability of the racemic compound and conglomerate was determined at both room temperature and the melting point. Crystallizations from melt and solution are shown to offer potential crystallization pathways to the conglomerate, provided crystallization of the racemic compound can be avoided. © 2011 American Chemical Society.

Original language	English
Pages (from-to)	1549-1556
Number of pages	7
Journal	Crystal Growth and Design
Volume	11
Issue number	5
DOIs	https://doi.org/10.1021/cg1015077
Publication status	Published - 4 May 2011

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10.1021/cg1015077

CCDC 778767: Experimental Crystal Structure Determination
Lorenz, H. (Contributor), Von Langermann, J. (Contributor), Sadiq, G. (Contributor), Seaton, C. C. (Contributor), Davey, R. (Contributor) & Seidel-Morgenstern, A. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/ccv4cjv, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv4cjv&sid=DataCite
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title = "The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate",

abstract = "Crystallization of racemic 2-chloromandelic acid yields a metastable conglomerate in addition to a more stable racemic compound. The crystal structure of the pure enantiomer is reported and the relative stability of the racemic compound and conglomerate was determined at both room temperature and the melting point. Crystallizations from melt and solution are shown to offer potential crystallization pathways to the conglomerate, provided crystallization of the racemic compound can be avoided. {\textcopyright} 2011 American Chemical Society.",

author = "Heike Lorenz and {Von Langermann}, Jan and Ghazla Sadiq and Seaon, {Colin C.} and Davey, {Roger J.} and Andreas Seidel-Morgenstern",

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T1 - The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate

AU - Lorenz, Heike

AU - Von Langermann, Jan

AU - Sadiq, Ghazla

AU - Seaon, Colin C.

AU - Davey, Roger J.

AU - Seidel-Morgenstern, Andreas

PY - 2011/5/4

Y1 - 2011/5/4

N2 - Crystallization of racemic 2-chloromandelic acid yields a metastable conglomerate in addition to a more stable racemic compound. The crystal structure of the pure enantiomer is reported and the relative stability of the racemic compound and conglomerate was determined at both room temperature and the melting point. Crystallizations from melt and solution are shown to offer potential crystallization pathways to the conglomerate, provided crystallization of the racemic compound can be avoided. © 2011 American Chemical Society.

AB - Crystallization of racemic 2-chloromandelic acid yields a metastable conglomerate in addition to a more stable racemic compound. The crystal structure of the pure enantiomer is reported and the relative stability of the racemic compound and conglomerate was determined at both room temperature and the melting point. Crystallizations from melt and solution are shown to offer potential crystallization pathways to the conglomerate, provided crystallization of the racemic compound can be avoided. © 2011 American Chemical Society.

U2 - 10.1021/cg1015077

DO - 10.1021/cg1015077

M3 - Article

SN - 1528-7483

VL - 11

SP - 1549

EP - 1556

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 5

ER -

The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate

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CCDC 778767: Experimental Crystal Structure Determination

Cite this