Abstract
The ribonuclease inhibitor from human placenta is a tight-binding inhibitor of alkaline and neutral ribonucleases, including the blood vessel-inducing protein, angiogenin. The location of the inhibitor gene within the human genome has now been determined. Utilizing human-rodent hybrid cell lines, it was found on chromosome 11. The localization was refined to chromosome band 11p15 by in situ hybridization of the ribonuclease inhibitor cDNA to normal metaphase chromosomes. A further refinement was obtained by in situ hybridization of the probe to metaphase chromosomes from RPMI 8402 cells, a line containing a well-characterized translocation t(11;14)(p15;q11) with a chromosome 11 breakpoint between the insulin-like growth factor 2 (IGF2) and Harvey rat sarcoma viral oncogene homolog genes. This analysis has localized the ribonuclease inhibitor gene to chromosome subband 11p15.5, distal to the IGF2 gene.
| Original language | English |
|---|---|
| Pages (from-to) | 717-21 |
| Number of pages | 5 |
| Journal | Genomics |
| Volume | 8 |
| Issue number | 4 |
| Publication status | Published - Dec 1990 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Cell Line
- Chromosome Banding
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Cricetinae
- Female
- Genes
- Humans
- Hybrid Cells
- Insulin-Like Growth Factor II
- Mice
- Nucleic Acid Hybridization
- Oncogenes
- Placenta
- Placental Hormones
- Ribonucleases
- Translocation, Genetic
- Journal Article
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S.
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