The polymorphic epithelial mucin MUC1 in human endometrium is regulated with maximal expression in the implantation phase

Neil A. Hey, Rosalind A. Graham, Mourad W. Seif, John D. Aplin

    Research output: Contribution to journalArticlepeer-review

    Abstract

    After ovulation, progesterone stimulates a temporally regulated secretory transformation in human endometrial epithelium. Using a combination of immunohistochemistry, and Western and Northern blotting, we demonstrate that 1) the polymorphic epithelial mucin MUC1 is secreted by human endometrial epithelium; 2) low levels of both mRNA and core protein are present in the preovulatory phase of the menstrual cycle; 3) mRNA levels increase several- fold after ovulation, consistent with transcriptional regulation by progesterone; 4) there is an increase in translation product in postovulatory endometrium; and 5) the tandem repeat domain of the MUC-1 polypeptide is glycosylated in endometrium.
    Original languageEnglish
    Pages (from-to)337-342
    Number of pages5
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume78
    Issue number2
    DOIs
    Publication statusPublished - Feb 1994

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