The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer

S. L. Schor; A. M. Schor; A. Howell; J. Haggie

doi:10.1007/978-1-4613-1753-1_10

The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer

S. L. Schor, A. M. Schor, A. Howell, J. Haggie

Division of Cancer Sciences (L5)

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Abstract

Fibroblasts obtained from patients with epithelial tumors have generally been considered to be normal cells. There is, however, a growing body of data indicating these fibroblasts may express a number of aberrant behavioral characteristics commonly associated with transformation. In this communication, we shall (a) review the evidence for the presence of such aberrant fibroblasts in cancer patients, (b) discuss the possible role played by these cells in the pathogenesis of breast cancer, and (c) consider the clinical implications of these findings.

Original language	English
Title of host publication	Breast Cancer: Scientific and Clinical Progress
Editors	Marvin A. Rich, Jean C. Hager, Diana M. Lopez
Publisher	Springer Nature
Pages	142-157
ISBN (Electronic)	978-1-4613-1753-1
ISBN (Print)	978-1-4612-8984-5
DOIs	https://doi.org/10.1007/978-1-4613-1753-1_10
Publication status	Published - 1988

Keywords

Breast Cancer
Breast Cancer Patient
Migratory Behavior
Hereditary Breast Cancer
Sporadic Breast Cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4613-1753-1_10

Cite this

@inbook{6016408c3c2d4153a58e125b58b0f856,

title = "The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer",

abstract = "Fibroblasts obtained from patients with epithelial tumors have generally been considered to be normal cells. There is, however, a growing body of data indicating these fibroblasts may express a number of aberrant behavioral characteristics commonly associated with transformation. In this communication, we shall (a) review the evidence for the presence of such aberrant fibroblasts in cancer patients, (b) discuss the possible role played by these cells in the pathogenesis of breast cancer, and (c) consider the clinical implications of these findings.",

keywords = "Breast Cancer , Breast Cancer Patient, Migratory Behavior, Hereditary Breast Cancer, Sporadic Breast Cancer ",

author = "Schor, {S. L.} and Schor, {A. M.} and A. Howell and J. Haggie",

year = "1988",

doi = "10.1007/978-1-4613-1753-1_10",

language = "English",

isbn = "978-1-4612-8984-5",

pages = "142--157",

editor = "Rich, {Marvin A.} and Hager, {Jean C.} and Lopez, {Diana M.}",

booktitle = "Breast Cancer: Scientific and Clinical Progress",

publisher = "Springer Nature",

address = "United States",

}

TY - CHAP

T1 - The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer

AU - Schor, S. L.

AU - Schor, A. M.

AU - Howell, A.

AU - Haggie, J.

PY - 1988

Y1 - 1988

N2 - Fibroblasts obtained from patients with epithelial tumors have generally been considered to be normal cells. There is, however, a growing body of data indicating these fibroblasts may express a number of aberrant behavioral characteristics commonly associated with transformation. In this communication, we shall (a) review the evidence for the presence of such aberrant fibroblasts in cancer patients, (b) discuss the possible role played by these cells in the pathogenesis of breast cancer, and (c) consider the clinical implications of these findings.

AB - Fibroblasts obtained from patients with epithelial tumors have generally been considered to be normal cells. There is, however, a growing body of data indicating these fibroblasts may express a number of aberrant behavioral characteristics commonly associated with transformation. In this communication, we shall (a) review the evidence for the presence of such aberrant fibroblasts in cancer patients, (b) discuss the possible role played by these cells in the pathogenesis of breast cancer, and (c) consider the clinical implications of these findings.

KW - Breast Cancer

KW - Breast Cancer Patient

KW - Migratory Behavior

KW - Hereditary Breast Cancer

KW - Sporadic Breast Cancer

U2 - 10.1007/978-1-4613-1753-1_10

DO - 10.1007/978-1-4613-1753-1_10

M3 - Chapter

SN - 978-1-4612-8984-5

SP - 142

EP - 157

BT - Breast Cancer: Scientific and Clinical Progress

A2 - Rich, Marvin A.

A2 - Hager, Jean C.

A2 - Lopez, Diana M.

PB - Springer Nature

ER -

The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this