The Potential of Polyethylene Terephthalate Glycol as Biomaterial for Bone Tissue Engineering

Mohamed Hassan, Abdalla Omar, Evangelos Daskalakis, Yanhao Hou, Boyang Huang, Ilya Strashnov, Bruce Grieve, Paulo Bartolo,

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Abstract

The search for materials with improved mechanical and biological properties is a
major challenge in tissue engineering. This paper investigates, for the first time, the use of Polyethylene Terephthalate Glycol (PETG), a glycol-modified class of Polyethylene Terephthalate (PET), as a potential material for the fabrication of bone scaffolds. PETG scaffolds with a 0/90 lay-dawn pattern and different pore sizes (300, 350 and 450 um) were produced using a filament-based extrusion
additive manufacturing system and mechanically and biologically characterized. The performance of PETG scaffolds with 300 um of pore size was compared with polycaprolactone (PCL). Results show that PETG scaffolds present significantly higher mechanical properties than PCL scaffolds, providing a biomechanical environment that promotes high cell attachment and proliferation.
Original languageEnglish
Number of pages12
JournalPolymers
Volume12
Issue number12
DOIs
Publication statusPublished - 18 Dec 2020

Keywords

  • Biomaterial
  • Polyethylene terephthalate glycol
  • Tissue engineering

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