The potential of positron-emission tomography to study anticancer-drug resistance

Catharine M L West; Terry Jones; Pat Price

The potential of positron-emission tomography to study anticancer-drug resistance

Catharine M L West, Terry Jones, Pat Price

Research output: Contribution to journal › Article › peer-review

Abstract

Positron-emission tomography (PET) is a powerful tool for imaging and quantifying cellular and molecular processes in humans. It has enormous potential to increase our understanding of the pathophysiology of human tumours and to support the development of anticancer drugs. The ability of PET to image mechanisms of anticancer-drug resistance in vivo should be exploited in proof-of-concept studies at early stages of drug development.

Original language	English
Pages (from-to)	457-469
Number of pages	12
Journal	Nature Reviews Cancer
Volume	4
Issue number	6
Publication status	Published - Jun 2004

Keywords

pharmacokinetics: Antineoplastic Agents
Drug Resistance, Neoplasm
Humans
physiopathology: Neoplasms
Tomography, Emission-Computed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The potential of positron-emission tomography to study anticancer-drug resistance",

abstract = "Positron-emission tomography (PET) is a powerful tool for imaging and quantifying cellular and molecular processes in humans. It has enormous potential to increase our understanding of the pathophysiology of human tumours and to support the development of anticancer drugs. The ability of PET to image mechanisms of anticancer-drug resistance in vivo should be exploited in proof-of-concept studies at early stages of drug development.",

keywords = "pharmacokinetics: Antineoplastic Agents, Drug Resistance, Neoplasm, Humans, physiopathology: Neoplasms, Tomography, Emission-Computed",

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year = "2004",

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AU - West, Catharine M L

AU - Jones, Terry

AU - Price, Pat

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N2 - Positron-emission tomography (PET) is a powerful tool for imaging and quantifying cellular and molecular processes in humans. It has enormous potential to increase our understanding of the pathophysiology of human tumours and to support the development of anticancer drugs. The ability of PET to image mechanisms of anticancer-drug resistance in vivo should be exploited in proof-of-concept studies at early stages of drug development.

AB - Positron-emission tomography (PET) is a powerful tool for imaging and quantifying cellular and molecular processes in humans. It has enormous potential to increase our understanding of the pathophysiology of human tumours and to support the development of anticancer drugs. The ability of PET to image mechanisms of anticancer-drug resistance in vivo should be exploited in proof-of-concept studies at early stages of drug development.

KW - pharmacokinetics: Antineoplastic Agents

KW - Drug Resistance, Neoplasm

KW - Humans

KW - physiopathology: Neoplasms

KW - Tomography, Emission-Computed

M3 - Article

SN - 1474-1768

VL - 4

SP - 457

EP - 469

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 6

ER -

The potential of positron-emission tomography to study anticancer-drug resistance

Abstract

Keywords

UN SDGs

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