The Potential of Unsaturated Polyesters in Biomedicine and Tissue Engineering: Synthesis, Structure-Properties Relationships and Additive Manufacturing

Filipa A M M Gonçalves; A C  Fonseca; Marco Domingos; A Gloria; A. Serra; Jorge F J Coelho

doi:10.1016/j.progpolymsci.2016.12.008

The Potential of Unsaturated Polyesters in Biomedicine and Tissue Engineering: Synthesis, Structure-Properties Relationships and Additive Manufacturing

Filipa A M M Gonçalves, A C Fonseca, Marco Domingos, A Gloria, A. Serra, Jorge F J Coelho

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Abstract

The success of Tissue Engineering (TE) based approaches is strongly dependent on the development of novel biomaterials for the design of 3D matrices with tailored biomechanical properties to promote the regeneration of human tissues and organs.

This review covers the critical aspects related with the preparation of new unsaturated polyester (UP) resin formulations with suitable biological, chemical, thermal and morphological properties for the additive manufacturing (AM) of TE constructs. In this context, the basic principles of available AM technologies, with a special focus on novel stereolithography processes such as microstereolithography (micro-SLA), stereo-thermal-lithography (STLA), two-photon polymerization (TPP) and nanostereolithography (nano-SLA), are also presented and discussed. Ultimately, the present review will provide a better insight into the limitations and potential of combining UP and AM towards the rationale design/fabrication of complex artificial tissue substitutes

Original language	English
Journal	Progress in Polymer Science
Early online date	13 Dec 2016
DOIs	https://doi.org/10.1016/j.progpolymsci.2016.12.008
Publication status	Published - 2016

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title = "The Potential of Unsaturated Polyesters in Biomedicine and Tissue Engineering: Synthesis, Structure-Properties Relationships and Additive Manufacturing",

abstract = "The success of Tissue Engineering (TE) based approaches is strongly dependent on the development of novel biomaterials for the design of 3D matrices with tailored biomechanical properties to promote the regeneration of human tissues and organs.This review covers the critical aspects related with the preparation of new unsaturated polyester (UP) resin formulations with suitable biological, chemical, thermal and morphological properties for the additive manufacturing (AM) of TE constructs. In this context, the basic principles of available AM technologies, with a special focus on novel stereolithography processes such as microstereolithography (micro-SLA), stereo-thermal-lithography (STLA), two-photon polymerization (TPP) and nanostereolithography (nano-SLA), are also presented and discussed. Ultimately, the present review will provide a better insight into the limitations and potential of combining UP and AM towards the rationale design/fabrication of complex artificial tissue substitutes",

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year = "2016",

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language = "English",

journal = "Progress in Polymer Science",

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AU - Gonçalves, Filipa A M M

AU - Fonseca, A C

AU - Domingos, Marco

AU - Gloria, A

AU - Serra, A.

AU - Coelho, Jorge F J

PY - 2016

Y1 - 2016

N2 - The success of Tissue Engineering (TE) based approaches is strongly dependent on the development of novel biomaterials for the design of 3D matrices with tailored biomechanical properties to promote the regeneration of human tissues and organs.This review covers the critical aspects related with the preparation of new unsaturated polyester (UP) resin formulations with suitable biological, chemical, thermal and morphological properties for the additive manufacturing (AM) of TE constructs. In this context, the basic principles of available AM technologies, with a special focus on novel stereolithography processes such as microstereolithography (micro-SLA), stereo-thermal-lithography (STLA), two-photon polymerization (TPP) and nanostereolithography (nano-SLA), are also presented and discussed. Ultimately, the present review will provide a better insight into the limitations and potential of combining UP and AM towards the rationale design/fabrication of complex artificial tissue substitutes

AB - The success of Tissue Engineering (TE) based approaches is strongly dependent on the development of novel biomaterials for the design of 3D matrices with tailored biomechanical properties to promote the regeneration of human tissues and organs.This review covers the critical aspects related with the preparation of new unsaturated polyester (UP) resin formulations with suitable biological, chemical, thermal and morphological properties for the additive manufacturing (AM) of TE constructs. In this context, the basic principles of available AM technologies, with a special focus on novel stereolithography processes such as microstereolithography (micro-SLA), stereo-thermal-lithography (STLA), two-photon polymerization (TPP) and nanostereolithography (nano-SLA), are also presented and discussed. Ultimately, the present review will provide a better insight into the limitations and potential of combining UP and AM towards the rationale design/fabrication of complex artificial tissue substitutes

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DO - 10.1016/j.progpolymsci.2016.12.008

M3 - Article

SN - 0079-6700

JO - Progress in Polymer Science

JF - Progress in Polymer Science

ER -

The Potential of Unsaturated Polyesters in Biomedicine and Tissue Engineering: Synthesis, Structure-Properties Relationships and Additive Manufacturing

Abstract

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