The predictive ability of triglycerides and waist (hypertriglyceridemic waist) in assessing metabolic triad change in obese children and adolescents

James P. Hobkirk; Roderick F. King; Paul Gately; Philip Pemberton; Alexander Smith; Julian H. Barth; Nicola Harman; Ian Davies; Sean Carroll

doi:10.1089/met.2012.0152

The predictive ability of triglycerides and waist (hypertriglyceridemic waist) in assessing metabolic triad change in obese children and adolescents

James P. Hobkirk, Roderick F. King, Paul Gately, Philip Pemberton, Alexander Smith, Julian H. Barth, Nicola Harman, Ian Davies, Sean Carroll

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The metabolic triad [fasting insulin, apolipoprotein B, and low-density lipoporotein (LDL) peak particle density] is characteristic of increased intra-abdominal adipose tissue and insulin resistance and can be predicted by the simple and adoptable screening tool, the hypertriglyceridemic waist. The associations between hypertriglyceridemic waist components [fasting triglycerides (TG) and waist circumference cut-points derived from a child-specific metabolic syndrome definition] with the metabolic triad were examined in obese youth before and after weight loss. Methods: A continuous metabolic triad score (MTS) was calculated as a cumulative and standardized residual score of fasting insulin, apolipoprotein B, and LDL peak particle density (z-scores of the metabolic triad variables regressed onto age and sex). The predictive ability of TG and waist in assessing metabolic triad change was undertaken in 75 clinically obese boys and girls, aged 8-18, body mass index (BMI) 34.2±6.4 kg/m2 before and after weight loss. Results: Fasting TG concentrations (r2=0.216, P

Original language	English
Pages (from-to)	336-342
Number of pages	6
Journal	Metabolic Syndrome and Related Disorders
Volume	11
Issue number	5
DOIs	https://doi.org/10.1089/met.2012.0152
Publication status	Published - 1 Oct 2013

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Hobkirk, J. P., King, R. F., Gately, P., Pemberton, P., Smith, A., Barth, J. H., Harman, N., Davies, I., & Carroll, S. (2013). The predictive ability of triglycerides and waist (hypertriglyceridemic waist) in assessing metabolic triad change in obese children and adolescents. Metabolic Syndrome and Related Disorders, 11(5), 336-342. https://doi.org/10.1089/met.2012.0152

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title = "The predictive ability of triglycerides and waist (hypertriglyceridemic waist) in assessing metabolic triad change in obese children and adolescents",

abstract = "Background: The metabolic triad [fasting insulin, apolipoprotein B, and low-density lipoporotein (LDL) peak particle density] is characteristic of increased intra-abdominal adipose tissue and insulin resistance and can be predicted by the simple and adoptable screening tool, the hypertriglyceridemic waist. The associations between hypertriglyceridemic waist components [fasting triglycerides (TG) and waist circumference cut-points derived from a child-specific metabolic syndrome definition] with the metabolic triad were examined in obese youth before and after weight loss. Methods: A continuous metabolic triad score (MTS) was calculated as a cumulative and standardized residual score of fasting insulin, apolipoprotein B, and LDL peak particle density (z-scores of the metabolic triad variables regressed onto age and sex). The predictive ability of TG and waist in assessing metabolic triad change was undertaken in 75 clinically obese boys and girls, aged 8-18, body mass index (BMI) 34.2±6.4 kg/m2 before and after weight loss. Results: Fasting TG concentrations (r2=0.216, P",

author = "Hobkirk, {James P.} and King, {Roderick F.} and Paul Gately and Philip Pemberton and Alexander Smith and Barth, {Julian H.} and Nicola Harman and Ian Davies and Sean Carroll",

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AU - Hobkirk, James P.

AU - King, Roderick F.

AU - Gately, Paul

AU - Pemberton, Philip

AU - Smith, Alexander

AU - Barth, Julian H.

AU - Harman, Nicola

AU - Davies, Ian

AU - Carroll, Sean

PY - 2013/10/1

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N2 - Background: The metabolic triad [fasting insulin, apolipoprotein B, and low-density lipoporotein (LDL) peak particle density] is characteristic of increased intra-abdominal adipose tissue and insulin resistance and can be predicted by the simple and adoptable screening tool, the hypertriglyceridemic waist. The associations between hypertriglyceridemic waist components [fasting triglycerides (TG) and waist circumference cut-points derived from a child-specific metabolic syndrome definition] with the metabolic triad were examined in obese youth before and after weight loss. Methods: A continuous metabolic triad score (MTS) was calculated as a cumulative and standardized residual score of fasting insulin, apolipoprotein B, and LDL peak particle density (z-scores of the metabolic triad variables regressed onto age and sex). The predictive ability of TG and waist in assessing metabolic triad change was undertaken in 75 clinically obese boys and girls, aged 8-18, body mass index (BMI) 34.2±6.4 kg/m2 before and after weight loss. Results: Fasting TG concentrations (r2=0.216, P

AB - Background: The metabolic triad [fasting insulin, apolipoprotein B, and low-density lipoporotein (LDL) peak particle density] is characteristic of increased intra-abdominal adipose tissue and insulin resistance and can be predicted by the simple and adoptable screening tool, the hypertriglyceridemic waist. The associations between hypertriglyceridemic waist components [fasting triglycerides (TG) and waist circumference cut-points derived from a child-specific metabolic syndrome definition] with the metabolic triad were examined in obese youth before and after weight loss. Methods: A continuous metabolic triad score (MTS) was calculated as a cumulative and standardized residual score of fasting insulin, apolipoprotein B, and LDL peak particle density (z-scores of the metabolic triad variables regressed onto age and sex). The predictive ability of TG and waist in assessing metabolic triad change was undertaken in 75 clinically obese boys and girls, aged 8-18, body mass index (BMI) 34.2±6.4 kg/m2 before and after weight loss. Results: Fasting TG concentrations (r2=0.216, P

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SN - 1540-4196

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JO - Metabolic Syndrome and Related Disorders

JF - Metabolic Syndrome and Related Disorders

IS - 5

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The predictive ability of triglycerides and waist (hypertriglyceridemic waist) in assessing metabolic triad change in obese children and adolescents

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