TY - JOUR
T1 - The prevalence and predictors of an abnormal ankle-brachial index in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial
AU - Rutter, Martin
AU - Singh, Premranjan P.
AU - Abbott, J. Dawn
AU - Lombardero, Manuel S.
AU - Sutton-Tyrrell, Kim
AU - Woodhead, Gail
AU - Venkitachalam, Lakshmi
AU - Tsapatsaris, Nicholas P.
AU - Piemonte, Thomas C.
AU - Lago, Rodrigo M.
AU - Rutter, Martin K.
AU - Nesto, Richard W.
PY - 2011/2
Y1 - 2011/2
N2 - OBJECTIVE - To examine ankle-brachial index (ABI) abnormalities in patients with type 2 diabetes and coronary artery disease (CAD). RESEARCH DESIGN AND METHODS - An ABI was obtained in 2,240 patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. ABIs were classified as: normal, 0.91-1.3; low, ≤0.9; high, >1.3; or noncompressible artery (NC). Baseline characteristics were examined according to ABI and by multivariate analysis. RESULTS - ABI was normal in 66%, low in 19%, and high in 8% of patients, and 6% of patients had NC. Of the low ABI patients, 68% were asymptomatic. Using normal ABI as referent, low ABI was independently associated with smoking, female sex, black race, hypertension, age, C-reactive protein, diabetes duration, and lower BMI. High ABI was associated with male sex, nonblack race, and higher BMI; and NC artery was associated with diabetes duration, higher BMI, and hypertension. CONCLUSIONS - ABI abnormalities are common and often asymptomatic in patients with type 2 diabetes and CAD. © 2011 by the American Diabetes Association.
AB - OBJECTIVE - To examine ankle-brachial index (ABI) abnormalities in patients with type 2 diabetes and coronary artery disease (CAD). RESEARCH DESIGN AND METHODS - An ABI was obtained in 2,240 patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. ABIs were classified as: normal, 0.91-1.3; low, ≤0.9; high, >1.3; or noncompressible artery (NC). Baseline characteristics were examined according to ABI and by multivariate analysis. RESULTS - ABI was normal in 66%, low in 19%, and high in 8% of patients, and 6% of patients had NC. Of the low ABI patients, 68% were asymptomatic. Using normal ABI as referent, low ABI was independently associated with smoking, female sex, black race, hypertension, age, C-reactive protein, diabetes duration, and lower BMI. High ABI was associated with male sex, nonblack race, and higher BMI; and NC artery was associated with diabetes duration, higher BMI, and hypertension. CONCLUSIONS - ABI abnormalities are common and often asymptomatic in patients with type 2 diabetes and CAD. © 2011 by the American Diabetes Association.
U2 - 10.2337/dc10-1734
DO - 10.2337/dc10-1734
M3 - Article
SN - 0149-5992
VL - 34
SP - 464
EP - 467
JO - Diabetes Care
JF - Diabetes Care
IS - 2
ER -
