The principles of nuclear structure

Dean A. Jackson

doi:10.1023/A:1024954123092

The principles of nuclear structure

Dean A. Jackson

Research output: Contribution to journal › Article › peer-review

Abstract

In multicellular eukaryotes, chromatin function is regulated by numerous extremely sophisticated mechanisms. Recent developments in our ability to monitor the organization and dynamic properties of the components involved in processes such as gene expression and DNA synthesis have emphasised how both global nuclear architecture and chromosome structure can influence these fundamental processes. This review sets out to evaluate our present views of the principles that dictate nuclear structure. Particular emphasis is placed on architectural themes and the concept of spatial epigenetics.

Original language	English
Pages (from-to)	387-401
Number of pages	14
Journal	Chromosome Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1023/A:1024954123092
Publication status	Published - 2003

Keywords

Chromosome structure
Gene expression
Nuclear architecture
Nuclear compartments
Nuclear matrix
Transcription

Access to Document

10.1023/A:1024954123092

Cite this

@article{40365c3646554b3c96c366afebcd42a8,

title = "The principles of nuclear structure",

abstract = "In multicellular eukaryotes, chromatin function is regulated by numerous extremely sophisticated mechanisms. Recent developments in our ability to monitor the organization and dynamic properties of the components involved in processes such as gene expression and DNA synthesis have emphasised how both global nuclear architecture and chromosome structure can influence these fundamental processes. This review sets out to evaluate our present views of the principles that dictate nuclear structure. Particular emphasis is placed on architectural themes and the concept of spatial epigenetics.",

keywords = "Chromosome structure, Gene expression, Nuclear architecture, Nuclear compartments, Nuclear matrix, Transcription",

author = "Jackson, \{Dean A.\}",

year = "2003",

doi = "10.1023/A:1024954123092",

language = "English",

volume = "11",

pages = "387--401",

journal = "Chromosome Research",

issn = "1573-6849",

publisher = "Springer Nature",

number = "5",

}

TY - JOUR

T1 - The principles of nuclear structure

AU - Jackson, Dean A.

PY - 2003

Y1 - 2003

N2 - In multicellular eukaryotes, chromatin function is regulated by numerous extremely sophisticated mechanisms. Recent developments in our ability to monitor the organization and dynamic properties of the components involved in processes such as gene expression and DNA synthesis have emphasised how both global nuclear architecture and chromosome structure can influence these fundamental processes. This review sets out to evaluate our present views of the principles that dictate nuclear structure. Particular emphasis is placed on architectural themes and the concept of spatial epigenetics.

AB - In multicellular eukaryotes, chromatin function is regulated by numerous extremely sophisticated mechanisms. Recent developments in our ability to monitor the organization and dynamic properties of the components involved in processes such as gene expression and DNA synthesis have emphasised how both global nuclear architecture and chromosome structure can influence these fundamental processes. This review sets out to evaluate our present views of the principles that dictate nuclear structure. Particular emphasis is placed on architectural themes and the concept of spatial epigenetics.

KW - Chromosome structure

KW - Gene expression

KW - Nuclear architecture

KW - Nuclear compartments

KW - Nuclear matrix

KW - Transcription

U2 - 10.1023/A:1024954123092

DO - 10.1023/A:1024954123092

M3 - Article

C2 - 12971716

SN - 1573-6849

VL - 11

SP - 387

EP - 401

JO - Chromosome Research

JF - Chromosome Research

IS - 5

ER -

The principles of nuclear structure

Abstract

Keywords

Access to Document

Fingerprint

Cite this