The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British caucasian patients

H. Chinoy, H. Platt, J. A. Lamb, Z. Betteridge, H. Gunawardena, N. Fertig, H. Varsani, J. Davidson, C. V. Oddis, N. J. McHugh, L. R. Wedderburn, W. E R Ollier, R. G. Cooper

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    Abstract

    Objective. To examine single-nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase N22 gene (PTPN22) and to study the relationship between PTPN22 and the HLA region in patients with idiopathic inflammatory myopathies (IIMs). Methods. PTPN22 SNPs were assessed in a large, cross-sectional, case-control study from the UK involving patients with adult or juvenile IIM, comprising patients with polymyositis (PM) (n = 114), dermatomyositis (DM) (n = 102), myositis associated with another connective tissue disease (myositis-CTD overlap syndrome) (n = 64), or juvenile DM (n = 101), in comparison with 748 control subjects. Seventeen PTPN22 SNPs were genotyped using the Sequenom MassArray iPLEX platform. Serotyping for myositis-specific/myositis-associated autoantibodies (MSAs/MAAs) was performed by radioimmunoprecipitation. Results. A significant association was noted between the R620W variant (rs2476601) and IIM (corrected P [Pcorr] = 0.0009 versus controls), and specifically with the clinical subgroup of PM (Pcorr = 0.003 versus controls). A weaker association was noted with juvenile DM (Pcorr = 0.009 versus controls). No significant associations were noted after stratification by serologic subgroups. The association with the R620W variant was independent of alleles forming the HLA 8.1 haplotype. No other PTPN22 SNPs were associated with IIM. The PTPN22 haplotype containing the R620W T allele was the only haplotype significantly associated with IIM. Conclusion. The R620W variant is a significant risk factor for IIM, independent of the HLA 8.1 haplotype. Unlike that in the HLA region, risk is not increased in individuals possessing MSAs/MAAs. These results are further evidence that the PTPN22 gene confers autoimmune susceptibility. © 2008, American College of Rheumatology.
    Original languageEnglish
    Pages (from-to)3247-3254
    Number of pages7
    JournalArthritis Care & Research
    Volume58
    Issue number10
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • SYSTEMIC-LUPUS-ERYTHEMATOSUS
    • CLASS-II HAPLOTYPE
    • RHEUMATOID-ARTHRITIS
    • IMMUNOGENETIC RISK
    • PROTECTIVE FACTORS
    • REVISED CRITERIA
    • ALLELIC PROFILES
    • PTPN22
    • DERMATOMYOSITIS
    • MYOSITIS

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