TY - GEN
T1 - The Purkinje system and cardiac geometry
T2 - 5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009
AU - Romero, Daniel
AU - Sebastian, Rafael
AU - Bijnens, Bart H.
AU - Zimmerman, Viviana
AU - Boyle, Patrick M.
AU - Vigmond, Edward J.
AU - Frangi, Alejandro F.
PY - 2009
Y1 - 2009
N2 - Whole heart computer models are being widely used to assess treatment planning like Cardiac Resynchronization Therapy (CRT), a recognized treatment for heart failure. Certain aspects like cardiac geometry and the Purkinje system (PS) are still sometimes neglected on the studies. The present study includes a model of the human ventricles with incorporated anatomical structures such as myofibers orientation and Purkinje system. Two meshes representative of hypertrophic and dilated cardiomyopathies were generated from an original healthy subject mesh. In the context of (III) atrio-ventricular (AV) block, a sequential pacing protocol was tested for different device configurations. The pacing protocols were performed in models including the PS and in models lacking the PS. The results show that the Purkinje System leads to the synchronization of the septum and the left ventricle (LV) lateral wall, thus minimizing the interventricular delay. Also the modifications in the geometry resulted in changes in the activation patterns of the LV lateral wall, differing notably from physiological scenario.
AB - Whole heart computer models are being widely used to assess treatment planning like Cardiac Resynchronization Therapy (CRT), a recognized treatment for heart failure. Certain aspects like cardiac geometry and the Purkinje system (PS) are still sometimes neglected on the studies. The present study includes a model of the human ventricles with incorporated anatomical structures such as myofibers orientation and Purkinje system. Two meshes representative of hypertrophic and dilated cardiomyopathies were generated from an original healthy subject mesh. In the context of (III) atrio-ventricular (AV) block, a sequential pacing protocol was tested for different device configurations. The pacing protocols were performed in models including the PS and in models lacking the PS. The results show that the Purkinje System leads to the synchronization of the septum and the left ventricle (LV) lateral wall, thus minimizing the interventricular delay. Also the modifications in the geometry resulted in changes in the activation patterns of the LV lateral wall, differing notably from physiological scenario.
KW - Cardiac electrophysiology
KW - Cardiac Resynchronization Therapy
KW - Patient-specific geometry
KW - Purkinje system
KW - Ventricular pacing
UR - http://www.scopus.com/inward/record.url?scp=68849086312&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-01932-6_8
DO - 10.1007/978-3-642-01932-6_8
M3 - Conference contribution
AN - SCOPUS:68849086312
SN - 3642019315
SN - 9783642019319
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 68
EP - 77
BT - Functional Imaging and Modeling of the Heart
Y2 - 3 June 2009 through 5 June 2009
ER -