The relative abundance of dopamine D4 receptor mRNA in post mortem brains of schizophrenics and controls

D A Roberts; D Balderson; S M Pickering-Brown; J F Deakin; F Owen

The relative abundance of dopamine D4 receptor mRNA in post mortem brains of schizophrenics and controls

D A Roberts, D Balderson, S M Pickering-Brown, J F Deakin, F Owen

Division of Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

An increase in dopamine D4 receptors has recently been reported in post mortem brain samples from schizophrenics. We have attempted to complement this finding by assessing the levels of the specific messenger RNA (mRNA) for the D4 receptor, using the technique of quantitative RNA-PCR. No significant differences in the levels of expression of mRNA for the D4 receptor were found in the brains from schizophrenics compared to controls. The relationship between D4 receptors and schizophrenia, therefore, remains unclear.

Original language	English
Pages (from-to)	171-4
Number of pages	4
Journal	Schizophrenia Research
Volume	20
Issue number	1-2
Publication status	Published - May 1996

Keywords

Adult
Aged
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Polymerase Chain Reaction
RNA, Messenger
Receptors, Dopamine D2
Receptors, Dopamine D4
Reference Values
Schizophrenia
Journal Article

Cite this

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title = "The relative abundance of dopamine D4 receptor mRNA in post mortem brains of schizophrenics and controls",

abstract = "An increase in dopamine D4 receptors has recently been reported in post mortem brain samples from schizophrenics. We have attempted to complement this finding by assessing the levels of the specific messenger RNA (mRNA) for the D4 receptor, using the technique of quantitative RNA-PCR. No significant differences in the levels of expression of mRNA for the D4 receptor were found in the brains from schizophrenics compared to controls. The relationship between D4 receptors and schizophrenia, therefore, remains unclear.",

keywords = "Adult, Aged, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Polymerase Chain Reaction, RNA, Messenger, Receptors, Dopamine D2, Receptors, Dopamine D4, Reference Values, Schizophrenia, Journal Article",

author = "Roberts, {D A} and D Balderson and Pickering-Brown, {S M} and Deakin, {J F} and F Owen",

year = "1996",

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AU - Balderson, D

AU - Pickering-Brown, S M

AU - Deakin, J F

AU - Owen, F

PY - 1996/5

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AB - An increase in dopamine D4 receptors has recently been reported in post mortem brain samples from schizophrenics. We have attempted to complement this finding by assessing the levels of the specific messenger RNA (mRNA) for the D4 receptor, using the technique of quantitative RNA-PCR. No significant differences in the levels of expression of mRNA for the D4 receptor were found in the brains from schizophrenics compared to controls. The relationship between D4 receptors and schizophrenia, therefore, remains unclear.

KW - Adult

KW - Aged

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - RNA, Messenger

KW - Receptors, Dopamine D2

KW - Receptors, Dopamine D4

KW - Reference Values

KW - Schizophrenia

KW - Journal Article

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SN - 0920-9964

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JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-2

ER -

The relative abundance of dopamine D4 receptor mRNA in post mortem brains of schizophrenics and controls

Abstract

Keywords

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