TY - JOUR
T1 - The role of amylin in the insulin resistance of non-insulin-dependent diabetes mellitus
AU - Leighton, Brendan
AU - Cooper, Garth
PY - 1990/8
Y1 - 1990/8
N2 - Decreased responsiveness of glucose metabolism to insulin in skeletal muscle and the liver (insulin resistance or insensitivity) is characteristic of many conditions, including non-insulin-dependent (type II) diabetes mellitus. Most current work in this area centres on the hypothesis that the primary defect is an impairment of insulin binding and/or transduction of the insulin signal in affected tissues. However, studies imply that defects in the post-insulin receptor signalling pathways are of primary importance in the causation of insulin resistance. Amylin, a novel pancreatic hormone, secreted along with insulin from the pancreatic β-cells, can modulate insulin effects, to produce insulin resistance in skeletal muscle and liver. © 1990.
AB - Decreased responsiveness of glucose metabolism to insulin in skeletal muscle and the liver (insulin resistance or insensitivity) is characteristic of many conditions, including non-insulin-dependent (type II) diabetes mellitus. Most current work in this area centres on the hypothesis that the primary defect is an impairment of insulin binding and/or transduction of the insulin signal in affected tissues. However, studies imply that defects in the post-insulin receptor signalling pathways are of primary importance in the causation of insulin resistance. Amylin, a novel pancreatic hormone, secreted along with insulin from the pancreatic β-cells, can modulate insulin effects, to produce insulin resistance in skeletal muscle and liver. © 1990.
U2 - 10.1016/0968-0004(90)90015-4
DO - 10.1016/0968-0004(90)90015-4
M3 - Article
C2 - 2204154
SN - 0968-0004
VL - 15
SP - 295
EP - 299
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 8
ER -
