The role of breast cancer stem cells in metastasis and therapeutic implications

Marco A. Velasco-Velázquez; Vladimir M. Popov; Michael P. Lisanti; Richard G. Pestell

doi:10.1016/j.ajpath.2011.03.005

The role of breast cancer stem cells in metastasis and therapeutic implications

Marco A. Velasco-Velázquez
, Vladimir M. Popov
, Michael P. Lisanti
, Richard G. Pestell

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, and clinical outcome of cancers. In contrast, analysis of the role of CSCs in metastasis has been mainly conceptual and speculative. This review summarizes recent data that support the theory of CSCs as the source of metastatic lesions in breast cancer, with a focus on the key role of the microenvironment in the stemness-metastasis link. © 2011 American Society for Investigative Pathology.

Original language	English
Pages (from-to)	2-11
Number of pages	9
Journal	American journal of pathology
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.ajpath.2011.03.005
Publication status	Published - Jul 2011

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SDG 3 Good Health and Well-being

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10.1016/j.ajpath.2011.03.005

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title = "The role of breast cancer stem cells in metastasis and therapeutic implications",

abstract = "Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, and clinical outcome of cancers. In contrast, analysis of the role of CSCs in metastasis has been mainly conceptual and speculative. This review summarizes recent data that support the theory of CSCs as the source of metastatic lesions in breast cancer, with a focus on the key role of the microenvironment in the stemness-metastasis link. {\textcopyright} 2011 American Society for Investigative Pathology.",

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AU - Velasco-Velázquez, Marco A.

AU - Popov, Vladimir M.

AU - Lisanti, Michael P.

AU - Pestell, Richard G.

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AB - Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, and clinical outcome of cancers. In contrast, analysis of the role of CSCs in metastasis has been mainly conceptual and speculative. This review summarizes recent data that support the theory of CSCs as the source of metastatic lesions in breast cancer, with a focus on the key role of the microenvironment in the stemness-metastasis link. © 2011 American Society for Investigative Pathology.

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The role of breast cancer stem cells in metastasis and therapeutic implications

Abstract

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