The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

Alan R.f. Godwin; Mukti Singh; Michael P. Lockhart-cairns; Yasmene Alanazi; Stuart A. Cain; Clair Baldock

doi:10.1016/j.matbio.2019.06.006

The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

Alan R.f. Godwin, Mukti Singh, Michael P. Lockhart-cairns, Yasmene Alanazi, Stuart A. Cain, Clair Baldock

Research output: Contribution to journal › Review article › peer-review

Abstract

Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most extracellular matrices. Fibrillin microfibrils have specific biomechanical properties to endow animal tissues with limited elasticity, a fundamental feature of the durable function of large blood vessels, skin and lungs. They also form a template for elastin deposition and provide a platform for microfibril-elastin binding proteins to interact in elastic fibre assembly. In addition to their structural role, fibrillin microfibrils mediate cell signalling via integrin and syndecan receptors, and microfibrils sequester transforming growth factor (TGF)β family growth factors within the matrix to provide a tissue store which is critical for homeostasis and remodelling.

Original language	English
Journal	Matrix Biology
Early online date	18 Jun 2019
DOIs	https://doi.org/10.1016/j.matbio.2019.06.006
Publication status	Published - 2019

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10.1016/j.matbio.2019.06.006

https://linkinghub.elsevier.com/retrieve/pii/S0945053X19301477

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title = "The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly",

abstract = "Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most extracellular matrices. Fibrillin microfibrils have specific biomechanical properties to endow animal tissues with limited elasticity, a fundamental feature of the durable function of large blood vessels, skin and lungs. They also form a template for elastin deposition and provide a platform for microfibril-elastin binding proteins to interact in elastic fibre assembly. In addition to their structural role, fibrillin microfibrils mediate cell signalling via integrin and syndecan receptors, and microfibrils sequester transforming growth factor (TGF)β family growth factors within the matrix to provide a tissue store which is critical for homeostasis and remodelling.",

author = "Godwin, {Alan R.f.} and Mukti Singh and Lockhart-cairns, {Michael P.} and Yasmene Alanazi and Cain, {Stuart A.} and Clair Baldock",

year = "2019",

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language = "English",

journal = "Matrix Biology",

issn = "0945-053X",

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T1 - The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

AU - Godwin, Alan R.f.

AU - Singh, Mukti

AU - Lockhart-cairns, Michael P.

AU - Alanazi, Yasmene

AU - Cain, Stuart A.

AU - Baldock, Clair

PY - 2019

Y1 - 2019

N2 - Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most extracellular matrices. Fibrillin microfibrils have specific biomechanical properties to endow animal tissues with limited elasticity, a fundamental feature of the durable function of large blood vessels, skin and lungs. They also form a template for elastin deposition and provide a platform for microfibril-elastin binding proteins to interact in elastic fibre assembly. In addition to their structural role, fibrillin microfibrils mediate cell signalling via integrin and syndecan receptors, and microfibrils sequester transforming growth factor (TGF)β family growth factors within the matrix to provide a tissue store which is critical for homeostasis and remodelling.

AB - Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most extracellular matrices. Fibrillin microfibrils have specific biomechanical properties to endow animal tissues with limited elasticity, a fundamental feature of the durable function of large blood vessels, skin and lungs. They also form a template for elastin deposition and provide a platform for microfibril-elastin binding proteins to interact in elastic fibre assembly. In addition to their structural role, fibrillin microfibrils mediate cell signalling via integrin and syndecan receptors, and microfibrils sequester transforming growth factor (TGF)β family growth factors within the matrix to provide a tissue store which is critical for homeostasis and remodelling.

U2 - 10.1016/j.matbio.2019.06.006

DO - 10.1016/j.matbio.2019.06.006

M3 - Review article

SN - 0945-053X

JO - Matrix Biology

JF - Matrix Biology

ER -

The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

Abstract

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