The role of focal-adhesion kinase in cancer - A new therapeutic opportunity

Egle Mcdonald, Gordon W. McLean, Neil O. Carragher, Egle Avizienyte, Jeff Evans, Valerie G. Brunton, Margaret C. Frame

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.
    Original languageEnglish
    Pages (from-to)505-515
    Number of pages10
    JournalNature Reviews Cancer
    Volume5
    Issue number7
    DOIs
    Publication statusPublished - Jul 2005

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