The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress

Seema Chakravarthi, Catherine E. Jessop, Neil J. Bulleid

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Glutathione is a ubiquitous molecule found in all parts of the cell where it fulfils a range of functions from detoxification to protection from oxidative damage. It provides the main redox buffer for cells and as such has been implicated in the formation of native disulphide bonds. However, the discovery of the enzyme Ero1 has called into question the exact role of glutathione in this process. In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress. © 2006 European Molecular Biology Organization.
    Original languageEnglish
    Pages (from-to)271-275
    Number of pages4
    JournalEMBO reports
    Volume7
    Issue number3
    DOIs
    Publication statusPublished - Mar 2006

    Keywords

    • Disulphide-bond formation
    • Endoplasmic reticulum
    • Glutathione
    • Oxidative stress
    • Reactive oxygen species

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