The role of neuropeptides in psoriasis

R. Saraceno; C. E. Kleyn; G. Terenghi; C. E M Griffiths

doi:10.1111/j.1365-2133.2006.07518.x

The role of neuropeptides in psoriasis

R. Saraceno, C. E. Kleyn, G. Terenghi, C. E M Griffiths

Research output: Contribution to journal › Article › peer-review

Abstract

The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene-related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis. © 2006 The Authors.

Original language	English
Pages (from-to)	876-882
Number of pages	6
Journal	British Journal of Dermatology
Volume	155
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2133.2006.07518.x
Publication status	Published - Nov 2006

Keywords

Calcitonin gene-related peptide
Nerve growth factor
Neurogenic inflammation
Neuropeptides
Psoriasis
Substance P

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10.1111/j.1365-2133.2006.07518.x

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title = "The role of neuropeptides in psoriasis",

abstract = "The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene-related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis. {\textcopyright} 2006 The Authors.",

keywords = "Calcitonin gene-related peptide, Nerve growth factor, Neurogenic inflammation, Neuropeptides, Psoriasis, Substance P",

author = "R. Saraceno and Kleyn, {C. E.} and G. Terenghi and Griffiths, {C. E M}",

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T1 - The role of neuropeptides in psoriasis

AU - Saraceno, R.

AU - Kleyn, C. E.

AU - Terenghi, G.

AU - Griffiths, C. E M

PY - 2006/11

Y1 - 2006/11

N2 - The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene-related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis. © 2006 The Authors.

AB - The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene-related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis. © 2006 The Authors.

KW - Calcitonin gene-related peptide

KW - Nerve growth factor

KW - Neurogenic inflammation

KW - Neuropeptides

KW - Psoriasis

KW - Substance P

U2 - 10.1111/j.1365-2133.2006.07518.x

DO - 10.1111/j.1365-2133.2006.07518.x

M3 - Article

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VL - 155

SP - 876

EP - 882

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 5

ER -

The role of neuropeptides in psoriasis

Abstract

Keywords

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