The role of retinoic acid in tolerance and immunity

Jason A. Hall; John R. Grainger; Sean P. Spencer; Yasmine Belkaid

doi:10.1016/j.immuni.2011.07.002

The role of retinoic acid in tolerance and immunity

Jason A. Hall, John R. Grainger, Sean P. Spencer, Yasmine Belkaid

Research output: Contribution to journal › Article › peer-review

Abstract

Vitamin A elicits a broad array of immune responses through its metabolite, retinoic acid (RA). Recent evidence indicates that loss of RA leads to impaired immunity, whereas excess RA can potentially promote inflammatory disorders. In this review, we discuss recent advances showcasing the crucial contributions of RA to both immunological tolerance and the elicitation of adaptive immune responses. Further, we provide a comprehensive overview of the cell types and factors that control the production of RA and discuss how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology. © 2011 Elsevier Inc.

Original language	English
Pages (from-to)	13-22
Number of pages	9
Journal	Immunity
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2011.07.002
Publication status	Published - 22 Jul 2011

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abstract = "Vitamin A elicits a broad array of immune responses through its metabolite, retinoic acid (RA). Recent evidence indicates that loss of RA leads to impaired immunity, whereas excess RA can potentially promote inflammatory disorders. In this review, we discuss recent advances showcasing the crucial contributions of RA to both immunological tolerance and the elicitation of adaptive immune responses. Further, we provide a comprehensive overview of the cell types and factors that control the production of RA and discuss how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology. {\textcopyright} 2011 Elsevier Inc.",

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AB - Vitamin A elicits a broad array of immune responses through its metabolite, retinoic acid (RA). Recent evidence indicates that loss of RA leads to impaired immunity, whereas excess RA can potentially promote inflammatory disorders. In this review, we discuss recent advances showcasing the crucial contributions of RA to both immunological tolerance and the elicitation of adaptive immune responses. Further, we provide a comprehensive overview of the cell types and factors that control the production of RA and discuss how host perturbations may affect the ability of this metabolite to control tolerance and immunity or to instigate pathology. © 2011 Elsevier Inc.

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The role of retinoic acid in tolerance and immunity

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