The role of retinoids in the prevention and repair of aged and photoaged skin

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Retinoids, either naturally occurring or synthetic, are defined by their ability to bind nuclear retinoid receptors of the steroid/thyroid superfamily. Their protean but key function in physiology is control of cellular proliferation and differentiation. Topical retinoids, namely tretinoin, have been proven to prevent and repair clinical features of photoageing; these processes are facilitated by an ability to prevent loss of collagen from, and stimulate new collagen formation in, the papillary dermis of sun-exposed skin. Emerging evidence indicates that intrinsic, chronological ageing of the skin shares several mechanistic features with photoageing. Indeed aged skin is characterized by retinoid sensitivity and is probably reparable by application of topical retinoids.
    Original languageEnglish
    Pages (from-to)613-618
    Number of pages5
    JournalClinical and Experimental Dermatology
    Volume26
    Issue number7
    DOIs
    Publication statusPublished - 2001

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