The role of Snu114p during pre-mRNA splicing

Lilyann Novak-Frazer; Lily Novak Frazer; Verity Nancollis; Raymond T. O'Keefe

doi:10.1042/BST0360551

The role of Snu114p during pre-mRNA splicing

Lilyann Novak-Frazer, Lily Novak Frazer, Verity Nancollis, Raymond T. O'Keefe

Research output: Contribution to journal › Article › peer-review

Abstract

Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA-protein complex called the spliceosome. A number of spliceosome proteins are required for assembly and remodelling of the spliceosome with pre-mRNA to orient the splice sites correctly and catalyse the two steps of splicing. The spliceosome protein Snu114p is a GTPase that is related to the translation elongation factor EF-2. Snu114p plays a key role in spliceosome remodelling. In the present review, we briefly summarize the current knowledge of the function of Snu114p in pre-mRNA splicing and the role it plays in spliceosome dynamics. ©The Authors.

Original language	English
Pages (from-to)	551-553
Number of pages	2
Journal	Biochemical Society Transactions
Volume	36
Issue number	3
DOIs	https://doi.org/10.1042/BST0360551
Publication status	Published - Jun 2008

Keywords

Elongation factor 2 (EF-2)
GTPase
Pre-mRNA splicing
Snu114p
Spliceosome
U5 small nuclear ribonucleoprotein (U5 snRNP)

Access to Document

10.1042/BST0360551

Cite this

@article{1fce2634a9a74ceb970d0e17a185d6ff,

title = "The role of Snu114p during pre-mRNA splicing",

abstract = "Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA-protein complex called the spliceosome. A number of spliceosome proteins are required for assembly and remodelling of the spliceosome with pre-mRNA to orient the splice sites correctly and catalyse the two steps of splicing. The spliceosome protein Snu114p is a GTPase that is related to the translation elongation factor EF-2. Snu114p plays a key role in spliceosome remodelling. In the present review, we briefly summarize the current knowledge of the function of Snu114p in pre-mRNA splicing and the role it plays in spliceosome dynamics. {\textcopyright}The Authors.",

keywords = "Elongation factor 2 (EF-2), GTPase, Pre-mRNA splicing, Snu114p, Spliceosome, U5 small nuclear ribonucleoprotein (U5 snRNP)",

author = "Lilyann Novak-Frazer and Frazer, {Lily Novak} and Verity Nancollis and O'Keefe, {Raymond T.}",

year = "2008",

month = jun,

doi = "10.1042/BST0360551",

language = "English",

volume = "36",

pages = "551--553",

journal = "Biochemical Society Transactions",

issn = "1470-8752",

publisher = "Portland Press Ltd",

number = "3",

}

TY - JOUR

T1 - The role of Snu114p during pre-mRNA splicing

AU - Novak-Frazer, Lilyann

AU - Frazer, Lily Novak

AU - Nancollis, Verity

AU - O'Keefe, Raymond T.

PY - 2008/6

Y1 - 2008/6

N2 - Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA-protein complex called the spliceosome. A number of spliceosome proteins are required for assembly and remodelling of the spliceosome with pre-mRNA to orient the splice sites correctly and catalyse the two steps of splicing. The spliceosome protein Snu114p is a GTPase that is related to the translation elongation factor EF-2. Snu114p plays a key role in spliceosome remodelling. In the present review, we briefly summarize the current knowledge of the function of Snu114p in pre-mRNA splicing and the role it plays in spliceosome dynamics. ©The Authors.

AB - Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA-protein complex called the spliceosome. A number of spliceosome proteins are required for assembly and remodelling of the spliceosome with pre-mRNA to orient the splice sites correctly and catalyse the two steps of splicing. The spliceosome protein Snu114p is a GTPase that is related to the translation elongation factor EF-2. Snu114p plays a key role in spliceosome remodelling. In the present review, we briefly summarize the current knowledge of the function of Snu114p in pre-mRNA splicing and the role it plays in spliceosome dynamics. ©The Authors.

KW - Elongation factor 2 (EF-2)

KW - GTPase

KW - Pre-mRNA splicing

KW - Snu114p

KW - Spliceosome

KW - U5 small nuclear ribonucleoprotein (U5 snRNP)

U2 - 10.1042/BST0360551

DO - 10.1042/BST0360551

M3 - Article

C2 - 18482006

SN - 1470-8752

VL - 36

SP - 551

EP - 553

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 3

ER -

The role of Snu114p during pre-mRNA splicing

Abstract

Keywords

Access to Document

Fingerprint

Cite this