The role of the cytoskeleton and molecular motors in endosomal dynamics.

Elizabeth Granger; Gavin McNee; Victoria Allan; Philip Woodman

doi:10.1016/j.semcdb.2014.04.011

The role of the cytoskeleton and molecular motors in endosomal dynamics.

Elizabeth Granger, Gavin McNee, Victoria Allan, Philip Woodman

Research output: Contribution to journal › Article › peer-review

Abstract

The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.

Original language	English
Pages (from-to)	20-29
Number of pages	10
Journal	Seminars in cell & developmental biology
Volume	31
DOIs	https://doi.org/10.1016/j.semcdb.2014.04.011 https://doi.org/10.1016/j.semcdb.2014.04.011
Publication status	Published - Jul 2014

Keywords

Dynein
Endosome
Kinesin
Lysosome
Myosin
Recycling

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title = "The role of the cytoskeleton and molecular motors in endosomal dynamics.",

abstract = "The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.",

keywords = "Dynein, Endosome, Kinesin, Lysosome, Myosin, Recycling",

author = "Elizabeth Granger and Gavin McNee and Victoria Allan and Philip Woodman",

note = "BB/H017828/1, Biotechnology and Biological Sciences Research Council, United KingdomG0600253, Medical Research Council, United KingdomG0701140, Medical Research Council, United KingdomG0900930, Medical Research Council, United KingdomGO900930/1, Medical Research Council, United KingdomWT086077MA, Wellcome Trust, United Kingdom",

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doi = "10.1016/j.semcdb.2014.04.011",

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AU - Granger, Elizabeth

AU - McNee, Gavin

AU - Allan, Victoria

AU - Woodman, Philip

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N2 - The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.

AB - The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.

KW - Dynein

KW - Endosome

KW - Kinesin

KW - Lysosome

KW - Myosin

KW - Recycling

U2 - 10.1016/j.semcdb.2014.04.011

DO - 10.1016/j.semcdb.2014.04.011

M3 - Article

C2 - 24727350

SN - 1096-3634

VL - 31

SP - 20

EP - 29

JO - Seminars in cell & developmental biology

JF - Seminars in cell & developmental biology

ER -

The role of the cytoskeleton and molecular motors in endosomal dynamics.

Abstract

Keywords

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