The role of viruses and of APOE in dementia

R. F. Itzhaki; C. B. Dobson; S. J. Shipley; M. A. Wozniak

doi:10.1196/annals.1297.003

The role of viruses and of APOE in dementia

R. F. Itzhaki, C. B. Dobson, S. J. Shipley, M. A. Wozniak

Research output: Contribution to journal › Article › peer-review

Abstract

The virus, herpes simplex virus type 1 (HSV1), when present in brain, acts together with the type 4 allele of the APOE gene, a known susceptibility factor in Alzheimer disease (AD), to confer a strong risk of AD; in carriers of the other two main alleles of the gene, the virus does not confer a risk. It also has been shown that the outcome of infection in the case of five diseases known to be caused by viruses is determined by APOE. It is hoped that the discovery of the involvement of HSV1 in AD will lead to future antiviral therapy and possibly to immunization against the virus in infancy.

Original language	English
Pages (from-to)	15-18
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1019
DOIs	https://doi.org/10.1196/annals.1297.003
Publication status	Published - 2004

Keywords

Alzheimer disease (AD)
APOE
Brain
DNA
Herpes simples virus type 1 (HSV1)
Virus

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10.1196/annals.1297.003

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title = "The role of viruses and of APOE in dementia",

abstract = "The virus, herpes simplex virus type 1 (HSV1), when present in brain, acts together with the type 4 allele of the APOE gene, a known susceptibility factor in Alzheimer disease (AD), to confer a strong risk of AD; in carriers of the other two main alleles of the gene, the virus does not confer a risk. It also has been shown that the outcome of infection in the case of five diseases known to be caused by viruses is determined by APOE. It is hoped that the discovery of the involvement of HSV1 in AD will lead to future antiviral therapy and possibly to immunization against the virus in infancy.",

keywords = "Alzheimer disease (AD), APOE, Brain, DNA, Herpes simples virus type 1 (HSV1), Virus",

author = "Itzhaki, {R. F.} and Dobson, {C. B.} and Shipley, {S. J.} and Wozniak, {M. A.}",

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AU - Dobson, C. B.

AU - Shipley, S. J.

AU - Wozniak, M. A.

PY - 2004

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N2 - The virus, herpes simplex virus type 1 (HSV1), when present in brain, acts together with the type 4 allele of the APOE gene, a known susceptibility factor in Alzheimer disease (AD), to confer a strong risk of AD; in carriers of the other two main alleles of the gene, the virus does not confer a risk. It also has been shown that the outcome of infection in the case of five diseases known to be caused by viruses is determined by APOE. It is hoped that the discovery of the involvement of HSV1 in AD will lead to future antiviral therapy and possibly to immunization against the virus in infancy.

AB - The virus, herpes simplex virus type 1 (HSV1), when present in brain, acts together with the type 4 allele of the APOE gene, a known susceptibility factor in Alzheimer disease (AD), to confer a strong risk of AD; in carriers of the other two main alleles of the gene, the virus does not confer a risk. It also has been shown that the outcome of infection in the case of five diseases known to be caused by viruses is determined by APOE. It is hoped that the discovery of the involvement of HSV1 in AD will lead to future antiviral therapy and possibly to immunization against the virus in infancy.

KW - Alzheimer disease (AD)

KW - APOE

KW - Brain

KW - DNA

KW - Herpes simples virus type 1 (HSV1)

KW - Virus

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DO - 10.1196/annals.1297.003

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SP - 15

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

The role of viruses and of APOE in dementia

Abstract

Keywords

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