The roles of Bid

Mauro Degli Esposti, M. Degli Esposti

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-mediated apoptosis in many cell systems. Bid action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c. However, the precise mechanism of (t)Bid action is unknown. To advance our knowledge, this review evaluates the basic steps of Bid activation-caspase cleavage, dissociation of tBid, and lipid-mediated mitochondrial relocation-and their structure-function aspects. Relevant current information is thoroughly examined to outline the problems that hamper our understanding of the possible roles of Bid in cell life and death, and suggest valuable directions for obtaining a clarification of its pro-apoptotic mechanism.
    Original languageEnglish
    Pages (from-to)433-440
    Number of pages7
    JournalApoptosis
    Volume7
    Issue number5
    DOIs
    Publication statusPublished - Oct 2002

    Keywords

    • Apoptosis
    • Bax
    • Bcl-2
    • BH3 domain
    • Bid
    • Cytochrome c
    • Death receptor
    • Fas
    • Lipid transfer protein
    • Mitochondria
    • Phospholipids
    • Protein oligomerization

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