The samarium(II)-mediated intermolecular couplings of ketones and β-alkoxyacrylates: A short asymmetric synthesis of an antifungal γ-butyrolactone

Nessan J. Kerrigan, Tejas Upadhyay, David J. Procter

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The samarium(II) iodide-mediated coupling of ketones with β-alkoxyacrylates gives β-hydroxy-γ-butyrolactones in moderate yield. The process has been applied to the asymmetric synthesis of an antifungal, γ-butyrolactone natural product. © 2004 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)9087-9090
    Number of pages3
    JournalTetrahedron Letters
    Volume45
    Issue number49
    DOIs
    Publication statusPublished - 29 Nov 2004

    Keywords

    • Antifungal
    • Intermolecular couplings
    • Natural product
    • Samarium(II) iodide

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