The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe

Iain M. Hagan

Research output: Contribution to journalArticlepeer-review

Abstract

Commitment to mitosis is regulated by a conserved protein kinase complex called MPF (mitosis-promoting factor). MPF activation triggers a positive-feedback loop that further promotes the activity of its activating phosphatase Cdc25 and is assumed to down-regulate the MPF-inhibitory kinase Wee1. Four protein kinases contribute to this amplification loop: MPF itself, Polo kinase, MAPK (mitogen-activated protein kinase) and Greatwall kinase. The fission yeast SPB (spindle pole body) component Cut12 plays a critical role in modulating mitotic commitment. In this review, I discuss the relationship between Cut12 and the fission yeast Polo kinase Plo1 in mitotic control. These results indicate that commitment to mitosis is co-ordinated by control networks on the spindle pole. I then describe how the Cut12/Plo1 control network links growth control signalling from TOR (target of rapamycin) and MAPK networks to the activation of MPF to regulate the timing of cell division. © The Authors Journal Compilation. © 2008 Biochemical Society.
Original languageEnglish
Pages (from-to)1097-1101
Number of pages4
JournalBiochemical Society Transactions
Volume36
Issue number5
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Mitogen-activated protein kinase (MAPK)
  • Mitosis-promoting factor (MPF)
  • Mitotic commitment
  • Polo kinase
  • Spindle pole body (SPB)
  • Yeast

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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