The structure of glibenclamide in the solid state

D. Sanz; R.M. Claramunt; I. Alkorta; G. Sánchez-Sanz; J. Elguero

doi:10.1002/mrc.2868

The structure of glibenclamide in the solid state

D. Sanz, R.M. Claramunt, I. Alkorta, G. Sánchez-Sanz, J. Elguero

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Abstract

The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected.

Original language	English
Pages (from-to)	246-255
Number of pages	10
Journal	Magnetic Resonance in Chemistry
Volume	50
Issue number	3
DOIs	https://doi.org/10.1002/mrc.2868
Publication status	Published - 1 Mar 2012

Keywords

SSNMR
GIAO
B3LYP/6-311++G(d,p)

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10.1002/mrc.2868

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AU - Elguero, J.

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The structure of glibenclamide in the solid state

Abstract

Keywords

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