The TB structural genomics consortium: A resource for Mycobacterium tuberculosis biology

T. C. Terwilliger, M. S. Park, G. S. Waldo, J. Berendzen, L. W. Hung, C. Y. Kim, C. V. Smith, J. C. Sacchettini, M. Bellinzoni, R. Bossi, E. De Rossi, A. Mattevi, A. Milano, G. Riccardi, M. Rizzi, M. M. Roberts, A. R. Coker, G. Fossati, P. Mascagni, A. R M CoatesS. P. Wood, C. W. Goulding, M. I. Apostol, D. H. Anderson, H. S. Gill, D. S. Eisenberg, B. Taneja, S. Mande, E. Pohl, V. Lamzin, P. Tucker, M. Wilmanns, C. Colovos, W. Meyer-Klaucke, A. W. Munro, K. J. McLean, K. R. Marshall, D. Leys, J. K. Yang, H. J. Yoon, B. I. Lee, M. G. Lee, J. E. Kwak, B. W. Han, J. Y. Lee, S. H. Baek, S. W. Suh, M. M. Komen, V. L. Arcus, E. N. Baker, J. S. Lott, W. Jacobs, T. Alber, B. Rupp

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium tuberculosis. The Consortium members hope to work together with other M. tuberculosis researchers to identify M. tuberculosis proteins for which structural information could provide important biological information, to analyze and interpret structures of M. tuberculosis proteins, and to work collaboratively to test ideas about M. tuberculosis protein function that are suggested by structure or related to structural information. This review describes the TB Structural Genomics Consortium and some of the proteins for which the Consortium is in the progress of determining three-dimensional structures. © 2003 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)223-249
    Number of pages26
    JournalTuberculosis
    Volume83
    Issue number4
    DOIs
    Publication statusPublished - 2003

    Keywords

    • Drug discovery
    • Mycobacterium tuberculosis
    • Protein structure
    • Structural genomics
    • X-ray crystallography

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